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Researchers discover new antifungal antibiotic isolated from a pathogenic bacterium in potatoes
A team of researchers from Europe, while searching for new compounds amid the growing threat of antimicrobial resistance, have reported the discovery of a new antifungal antibiotic named solanimycin in their study published in mBio. The results suggest that solanimycin and related compounds could be helpful in agricultural and clinical settings.
The compound was initially isolated from a pathogenic bacterium that infects potatoes and is produced by a broad spectrum of related plant pathogenic bacteria. Solanimycin acts against a wide range of fungi known to infect and wreak havoc on agricultural crops, according to the researchers. In lab studies, the compound also acted against Candida albicans, a fungus that occurs naturally in the body but can cause dangerous infections.
Soil microbes, especially from the Actinobacteria phylum, produce the most therapeutic antibiotics used today. The new discovery suggests plant-based microorganisms are worth a closer look, especially as crops develop resistance to existing treatments, says microbiologist Rita Monson, Ph.D., at the University of Cambridge. She co-led the study with molecular microbiologist Miguel Matilla, Ph.D., at the Spanish Research Council's Estación Experimental del ZaidÃn, in Granada.
"We have to look more expansively across much more of the microbial populations available to us," Monson said.
The pathogenic potato bacterium Dickeya solani, which produces solanimycin, was first identified more than 15 years ago. Researchers in the lab of molecular microbiologist George Salmond, Ph.D., at the University of Cambridge, began investigating its antibiotic potential about a decade ago.
"These strains emerged rapidly, and now they are widely distributed," said Matilla.
Solanimycin isn't the first antibiotic discovered from the microbe. In previous work, researchers found that D. solani produces an antibiotic called oocydin A, which is highly active against multiple fungal plant pathogens.
Those previous discoveries, together with the analysis of the genome of the bacterium, hinted that it might synthesize additional antibiotics, Matilla said, also with antifungal potential. That hint paid off: Matilla, Monson, Salmond and their colleagues found that when they silenced the genes responsible for the production of oocydin A, the bacterium continued to show antifungal activity.
That observation led to the identification of solanimycin and the identification of the gene clusters responsible for the proteins that make the compound.
The researchers found that the bacterium uses the compound sparingly, producing it in response to cell density. An acidic pH environment—as that present in a potato-also activates the solanimycin gene cluster. Monson said it almost looks like a clever protective mechanism.
"It's an antifungal that we believe that will work by killing fungal competitors, and the bacteria benefit so much from this," said Monson. "But you don't turn it on unless you're in a potato."
Monson said the researchers have begun collaborating with chemists to learn more about the molecular structure of solanimycin and better understand how it works. Then, she and Matilla said they hope to see continued testing of the compound in plant and animal models.
"Our future steps are focused on trying to use this antibiotic antifungal for plant protection," Matilla said. The research team sees the discovery as an encouraging sign that plant pathogens-like D. solani-could be coaxed to make compounds that may be used against diseases in plants and people.
"We have to open to the exploration of everything that's out there to find new antibiotics," Matilla said.
Reference:
Miguel A. Matilla, Rita E. Monson, Annabel Murphy, Muriel Schicketanz, Alison Rawlinson, Caia Duncan, Juan Mata, Finian Leeper, George P. C. Salmond, DOI: https://doi.org/10.1128/mbio.02472-22
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751