Rheumatoid arthritis tied to greater risk of developing aortic stenosis

Written By : Aditi |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-08-11T09:00:31+05:30 | Updated On 11 Aug 2023 1:20 PM IST

An Original Investigation published on July 31, 2023, entitled "Aortic Stenosis Risk in Rheumatoid Arthritis" has concluded that those with a history of Rheumatoid Arthritis have an increased risk of developing aortic stenosis or AS, undergoing aortic valve intervention, and AS-related death. In this study, 73 070 RA patients were matched with 639 268 patients without any history of rheumatoid arthritis.

It is known that an increased risk of ischemic cardiovascular disease has been associated with rheumatoid arthritis (RA) but the risk of aortic stenosis (AS) with RA is unknown.

This study is published in JAMA Internal Medicine.

Do rheumatoid arthritis (RA) increases the risk of developing aortic stenosis (AS)?

There is an increased ischemic cardiovascular disease risk associated with rheumatoid arthritis (RA), but there needs to be more research on the association between RA and aortic stenosis. In the present study, researchers examined the risk of incident AS, aortic valve intervention, AS-related death, and risk factors for AS development in 73 070 patients with RA with a mean age of 63.

These were matched with 639 268 patients without RA of mean age 61 years and 16 109 composite AS outcomes over 6 223 150 person-years.

The incidence rate of AS was 3.97 per 1000 person-years in RA patients and 2.45 per 1000 person-years in the control patients.

There was an association of Rheumatoid arthritis with an increased risk of composite AS, aortic valve intervention and AS-related death.

They concluded there is an increased risk of AS, aortic valve intervention and AS-related death in RA patients.Findings of this study suggest that RA is associated with a higher risk of developing AS as well as the subsequent risks of aortic valve intervention and AS-related death.

The study’s Limitations are related to the limited generalizability of the results, the possibility of misclassification, bias residual confounding, etc.

BDS, MDS in Periodontics and Implantology

Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751