Statins Show Promise in Controlling Severe Asthma Exacerbations

An extensive study three decades published in The Journal of Allergy and Clinical Immunology: In Practice found the potential benefits of statins in the management of adult asthma. ChulHyoung Park and team from Ajou University Medical Center, Korea found that statin use was associated with a reduced risk of severe asthma exacerbations and overall improved clinical outcomes.

Asthma, a chronic respiratory condition that affects millions globally, has a complex relationship with blood lipids. Emerging research suggests that blood lipids might play a role in airway inflammation in asthma. Furthermore, statins, commonly used to lower cholesterol, have been proposed to have anti-inflammatory effects that could benefit asthmatic individuals. However, this study aimed to clarify the long-term effectiveness of statins in asthma management within real-world settings.

For this, researchers delved into electronic medical records spanning 28 years. The study compared two groups of asthma patients: those who consistently used statins and those who did not but had normal blood lipid levels. The objective was to ascertain if statins contributed to better asthma control over the long term.

After conducting propensity score matching (PSM), a statistical method to balance the groups, the study included 545 adult asthma patients in both the statin and non-statin groups. The findings were:

The statin group exhibited a significantly lower risk of severe asthma exacerbations (HR 0.57, 95% CI 0.35–0.90). This suggests that statin users experienced fewer critical asthma episodes, which can be life-threatening and require immediate medical attention.

In addition to severe exacerbations, the overall risk of asthma exacerbations was also lower in the statin group (HR 0.71, 95% CI 0.52–0.96). This indicates that statins may contribute to better asthma control in adults.

The study's results highlights the potential benefits of statins in the chronic management of adult asthma. While the research does not confirm that statins are a cure for asthma, it suggests that they might be a valuable addition to current treatment strategies. Asthma patients and healthcare providers should take note of these findings. Further research is needed to fully understand the mechanisms by which statins might benefit asthma patients and to confirm these findings.

Source:

Park, C., Jang, J.-H., Kim, C., Lee, Y., Lee, E., Yang, H.-M., Park, R. W., & Park, H.-S. (2023). Real-world Effectiveness of Statin Therapy in Adult Asthma. In The Journal of Allergy and Clinical Immunology: In Practice. Elsevier BV. https://doi.org/10.1016/j.jaip.2023.10.029