Triglyceride-glucose index promising predictor of risk of gallstone, suggests study

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-12-18T21:30:43+05:30 | Updated On 18 Dec 2024 9:30 PM IST

A new study published in the Nature Science Reports showed that triglyceride-glucose (TyG) index is helpful in determining whether people are more likely to develop gallstone disease (GSD). The common gastrointestinal condition, gallstones affect 10% to 15% of persons worldwide, where this disease affects 10% to 20% of Americans, and the percentage is rising.

Cholecystitis, cholangitis, and gallbladder cancer are among the complications that might affect 3% to 8% of people with gallstones. These issues can occasionally even be fatal and can have major repercussions. According to earlier studies, diabetes, kidney stones, coronary heart disease, and other conditions are all closely linked to an elevated TyG index.

Triglycerides and fasting blood glucose are two biomarkers that are used in the TyG index to quantify insulin resistance (IR) and evaluate insulin sensitivity in the human body. So, Hongliang Li and colleagues used data from the National Health and Nutrition Examination Survey (NHANES) that spanned from 2017 to 2020 to look into the relationship between gallstones and the TyG index.

This objective of this survey was to evaluate the current state of health of the Americans. Every NHANES program participant gave their informed consent and freely took part in the study. In this study, subgroup analysis, logistic regression analysis, smooth curve fitting, and participant characteristics were used to assess the association between TyG index and gallstones.

Gallstones were reported by 403 of the 3870 people over the age of 20 in the research, representing a 10.4% prevalence rate. The incidence of gallstones rose by 41% for every unit rise in the TyG index after controlling for all confounding variables (OR 1.41, 95% CI 1.07, 1.86). Gallstones and the TyG index were positively correlated, according to the smooth curve fitting.

According to subgroup analysis, the TyG index significantly increased the incidence of gallstones in those under 50, women, the individuals with total cholesterol levels greater than 200 mg/dL, people with body mass index (BMI) greater than 25, and people without diabetes. Overall, the study finds a strong link between gallstone risk and a higher TyG index.

Reference:

Li, H., & Zhang, C. (2024). Association between triglyceride-glucose index and gallstones: a cross-sectional study. In Scientific Reports (Vol. 14, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s41598-024-68841-6

Nature Scientific Reportstriglyceride-glucose indexgallstones

Source : Clinical Gastroenterology and Hepatology

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751