Cranberries prevent urinary tract infections in women: Myth or reality?

Australia: Recent evidence has shown that consuming cranberry products effectively prevents urinary tract infection (UTI) before it starts.

A global study looking at the benefits of cranberry products published in Cochrane Reviews has determined cranberry juice and its supplements reduce the risk of repeat symptomatic UTIs in women by more than a quarter, in children by more than half, and in people susceptible to UTI following medical interventions by about 53%.

Drinking cranberry juice has long been a mythical prevention strategy for women who develop a urinary tract infection. Cranberry juice and healthcare supplements commonly including the fruit, such as capsules and tablets, have long been promoted as a readily available solution to ward off infection. Still, the most recent review in 2012, with evidence from 24 trials, showed no benefit from the products.

The medical scientists behind this updated review from Flinders University and The Children’s Hospital at Westmead aimed to update these findings as an important step in determining the effectiveness of cranberry products by looking at 50 more recent trials that included almost 9000 participants.

“This incredible result didn’t really surprise us, as we’re taught that when there’s more and better evidence, the truth will ultimately come out. UTIs are horrible and very common; about a third of women will experience one, as will many elderly people and also people with bladder issues from spinal cord injury or other conditions,” says the study lead author Dr. Gabrielle Williams.

“Even back in 1973, my mum was told to try cranberry juice to prevent her horrible and frequent UTIs; for her it’s been a saviour. Despite me niggling in her ear about evidence, she’s continued to take it daily, first as the nasty sour juice and in recent years, the easy to swallow capsules. As soon as she stops, wham the symptoms are back. As usual, it turns out that mum was right! Cranberry products can help some women prevent UTIs.”

Flinders University epidemiologist Dr. Jacqueline Stephens, a co-author of the study, says if the UTI persists untreated it can move to the kidneys and cause pain and more complications, including sepsis in very severe cases, so prevention is the most effective way to reduce risks.

“Most UTIs are effectively, and pretty quickly, treated with antibiotics, sometimes as little as one dose can cure the problem. Unfortunately, in some people, UTIs keep coming back. Some healthcare providers began suggesting it to their patients without being sure if or how it works. It was a harmless, easy option at the time. Even centuries ago, Native Americans reportedly ate cranberries for bladder problems, leading somewhat more recently to laboratory scientists exploring what it was in cranberries that helped and how it might work.”

“The studies we looked at included a range of methods to determine the benefits of cranberry products. The vast majority compared cranberry products with a placebo or no treatment for UTI and determined drinking cranberries as a juice or taking capsules reduced the number of UTIs in women with recurrent cases, in children and people susceptible to UTI’s following medical interventions such as bladder radiotherapy.”

“It’s also important to consider that few people reported any side effects, the most common being tummy pain based on the results. We also did not find enough information to determine if cranberry products are more or less effective than antibiotics or probiotics in preventing further UTIs.”

The data also shows no benefit for elderly people, pregnant women or people with bladder emptying problems.

Senior Author Professor Jonathan Craig, Vice President and Executive Dean of the College of Medicine & Public Health at Flinders University, says the real benefits of cranberry products became clear when the researchers expanded the scope of the review to include the most recently available clinical data.

“This is a review of the totality of the evidence; new findings might occur as new evidence emerges. In this case, the new evidence shows a very positive finding that cranberry juice can prevent UTI in susceptible people,” says Professor Craig.

“We have shown the efficacy of cranberry products for treating UTIs using all the evidence published on this topic since the mid-nineties. The earlier versions of this review didn’t have enough evidence to determine efficacy, and subsequent clinical trials showed varied results. Still, in this updated review, the volume of data has shown this new finding.”

The study authors conclude that while cranberry products do help prevent UTIs in women with frequent recurrence, more studies are needed to clarify further who with UTI would benefit most from cranberry products.

Reference:

Gabrielle Williams, Deirdre Hahn, Jacqueline H Stephens, Jonathan C Craig, Elisabeth M Hodson, Cranberries for preventing urinary tract infections, https://doi.org/10.1002/14651858.CD001321.pub6.