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  • Icariin Shows...

Icariin Shows Kidney-Protective Effects Against Contrast-Induced Injury: Study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-07-07T20:45:14+05:30  |  Updated On 8 July 2025 11:53 AM IST
Icariin Shows Kidney-Protective Effects Against Contrast-Induced Injury: Study
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Researchers have discovered in a new research that oral administration of icariin at a dose of 100 mg/kg demonstrated significant renoprotective effects by mitigating contrast-induced renal injury. The protective mechanisms included anti-inflammatory, anti-apoptotic, and antioxidant actions.

Currently, the use of contrast agents in interventional procedures and imaging has been increasing. Icariin, an active component of Epimedium, offers beneficial biological activities such as antioxidation and anti-inflammation.

Therefore, our study aimed to investigate the protective role of icariin and its underlying mechanisms against contrast-induced nephropathy (CIN). They divided twenty-four rats into four groups (n = 6 each): control group icariin-only treated group, contrast-induced nephropathy (CIN) group, and CIN+Icariin group, with six rats in each group. We performed renal function tests (serum creatinine and blood urea nitrogen (BUN) and histological evaluations.

Additionally, we measured malondialdehyde (MDA) and superoxide dismutase (SOD) levels in renal supernatant and used ELISA to quantify caspase-8, caspase-9, cytochrome c, Bcl-2 associated protein x (Bax), and B cell lymphoma/leukemia 2 protein (Bcl-2) levels. We assessed nuclear factor kappa beta (NF-κB) and interleukin-1 beta (IL-1β) gene expression and evaluated immunoexpression of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), CD68, and caspase-3.

Results: Icariin showed nephroprotective effects against CIN, demonstrated by reduced creatinine and BUN; decreased MDA, IL-6, NF-κB, TNF-α, IL-1β, CD68, caspase-8, caspase-9, Bax, and cytochrome c; and increased SOD and Bcl-2 levels. Renal histology improved in the CIN+Icariin group compared to CIN group. Oral administration of 100 mg/kg icariin exhibited renoprotective effects against contrast-induced renal injury through anti-inflammatory, anti-apoptotic, and antioxidant mechanisms.

Reference:

Hanan A. Elgendy, Amira Osman, Amira E. Farage, Medhat Taha, Sara Abubakr, Alaa.M. Badawy, Mohie Mahmoud Ibrahim, Ahmed Nabawy Ahmed Nasr, Hala Mahfouz, Tourki A.S. Baokbah, Ahmed shaban Abdelmonsef, Mohamed Ezzat Mahmoud, Ahmed Abdel-monem Elmetwally, Abdulrahman I. AbuAqil, Nora Elshehawy Helal, Icariin mitigates experimental contrast-induced nephropathy: Mechanistic insights, Tissue and Cell, Volume 96, 2025, 103020, ISSN 0040-8166, https://doi.org/10.1016/j.tice.2025.103020.

IcariinShowsKidney-ProtectiveEffectsAgainstContrast-InducedInjuryStudyTissue and Cell
Source : Tissue and Cell
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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