Kidney function decline at young age tied to worse cognitive performance later: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2020-11-04T19:33:39+05:30 | Updated On 5 Nov 2020 2:34 PM IST

USA: People who experience episodes of kidney function decline in their young adulthood are at greater risk for worse cognitive performance in their midlife, a recent study in the journal Neurology has suggested.

Sanaz Sedaghat, National Institute on Aging (L.J.L.), Baltimore, MD, and colleagues tested the hypothesis that end-stage renal disease (ESRD) risk exposure during young adulthood is related to worse cognitive performance in midlife.

For the purpose, the researchers included 2,604 participants from the population-based Coronary Artery Risk Development in Young Adults (CARDIA) Study (mean age 35 years, 54% women, 45% Black). Estimated glomerular filtration rate and albumin-to-creatinine ratio were measured every 5 years at year (Y) 10 through Y30.

At each visit, moderate/high risk of ESRD according to the Kidney Disease: Improving Global Outcomes guidelines (estimated glomerular filtration rate <60 mL/min/1.73 m2 or albumin-to-creatinine ratio >30 mg/g) was defined, totaled over examinations, and categorized into 0 episodes, 1 episode, and >1 episodes of ESRD risk. At Y30, participants underwent global and multidomain cognitive assessment.

Also Read: Blood sugar control in Diabetes patients may improve cognitive function: Study

Key findings of the study include:

· Over the course of 20 years, 427 participants (16% of the study population) had ≥1 episodes of ESRD risk exposure.

· Individuals with more risk episodes had lower composite cognitive function, psychomotor speed, and executive function.

· All these associations were independent of sociodemographic status and cardiovascular risk factors.

"In this study, we showed that episodes of decline in kidney function over the young-adulthood course are associated with worse cognitive performance at midlife. Preserving kidney function in young age needs to be investigated as a potential strategy to preserve cognitive function in midlife," the researchers concluded.

Also Read: Canagliflozin reduces anemia risk in patients with CKD and diabetes: Lancet

The study, "Decline in kidney function over the course of adulthood and cognitive function in midlife," is published in the journal Neurology.

DOI: https://n.neurology.org/content/95/17/e2389

journal Neurologykidney functioncognitive declineend-stage renal disease

Source : journal Neurology

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751