Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • MD Brand Connect
  • Vaccine Hub
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
  • Fact Check
  • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Fact Check
      • Bone Health Fact Check
      • Brain Health Fact Check
      • Cancer Related Fact Check
      • Child Care Fact Check
      • Dental and oral health fact check
      • Diabetes and metabolic health fact check
      • Diet and Nutrition Fact Check
      • Eye and ENT Care Fact Check
      • Fitness fact check
      • Gut health fact check
      • Heart health fact check
      • Kidney health fact check
      • Medical education fact check
      • Men's health fact check
      • Respiratory fact check
      • Skin and hair care fact check
      • Vaccine and Immunization fact check
      • Women's health fact check
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Abroad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
      • Medical Dialogues Show
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Fact Check
    • Bone Health Fact Check
    • Brain Health Fact Check
    • Cancer Related Fact Check
    • Child Care Fact Check
    • Dental and oral health fact check
    • Diabetes and metabolic health fact check
    • Diet and Nutrition Fact Check
    • Eye and ENT Care Fact Check
    • Fitness fact check
    • Gut health fact check
    • Heart health fact check
    • Kidney health fact check
    • Medical education fact check
    • Men's health fact check
    • Respiratory fact check
    • Skin and hair care fact check
    • Vaccine and Immunization fact check
    • Women's health fact check
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Abroad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Nephrology
  • Nephrology News
  • Oral daprodustat...

Oral daprodustat efficacious for raising hemoglobin levels among CKD patients: NEJM

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-11-10T09:00:30+05:30  |  Updated On 10 Nov 2021 9:18 AM IST
Oral daprodustat efficacious for raising hemoglobin levels among CKD patients: NEJM
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • Email

Anemia is a common and sometimes debilitating problem among patients with chronic kidney disease (CKD). Anemia can occur when the kidneys become damaged, limiting the production of erythropoietin (EPO) — a hormone that signals to the body to make red blood cells. Currently, patients with CKD and anemia are treated with erythropoiesis stimulating agents (ESAs), which must be given via subcutaneous injection or as part of dialysis.

Investigators from Brigham and Women's Hospital have found that Oral daprodustat is efficacious for raising hemoglobin levels among CKD patients.

Daprodustat is a drug belonging to new class of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF PH inhibitors) that can be given orally to treat anemia.

The ASCEND trials tested daprodustat in patients with CKD on dialysis and in patients with CKD not on dialysis and found that it was as safe and efficacious as erythropoiesis stimulating agents (ESAs) for raising their hemoglobin.

The results of two studies were published in The New England Journal of Medicine and presented at the meeting of American Society for Nephrology Kidney Week.

"Anemia is a problem for so many patients with CKD, and having to come to the hospital or give oneself a subcutaneous injection can become a bottleneck for treatment," said Ajay Singh, MBBS, of the Brigham's Division of Renal Medicine and lead investigator of the trials. "Oral treatment has the power to be transformative for patient care."

The development of prolyl hydroxylase inhibitors is based on discoveries on how cells sense and adapt to oxygen availability made by William G. Kaelin Jr., MD, of the Brigham and the Dana-Farber Cancer Institute, and collaborators. These discoveries were recognized with the Nobel Prize in Physiology or Medicine in 2019. While ESAs act as stand-ins for EPO to directly stimulate the production of red blood cells, HIF PH inhibitors act to stabilize proteins known as hypoxia inducible factors, coaxing the body to produce its own EPO and improving iron mobilization to the bone marrow.

Many safety concerns about ESAs have arisen over the years, including possible increased risk of stroke, myocardial infarction, vascular access thrombosis, tumor progression, and death. The phase 3 ASCEND trials evaluated cardiovascular safety as well as how effectively the HIF PH inhibitor increased hemoglobin. Major adverse cardiovascular events (MACE) were adjudicated by an independent committee throughout the trials.

Among 2,964 patients on dialysis who were randomly assigned to receive daprodustat or an ESA, hemoglobin levels rose 0.28±0.02 g per deciliter with daprodustat and 0.10±0.02 g per deciliter with ESA, meeting the trial's prespecified endpoint. MACE occurred in 374 of 1,487 (25.2 percent) and 394 of 1,477 (26.7 percent) participants in the daprodustat and ESA groups, respectively, meeting the trial's prespecified endpoint.

The team also reported on results among 3,872 patients not on dialysis. For those patients, hemoglobin levels also rose — 0.74±0.02 g per deciliter with daprodustat and 0.66±0.02 g per deciliter with an ESA, meeting the trial's prespecified endpoint. MACE occurred in 378 of 1,937 (19.5 percent) participants in the daprodustat group and in 371 of 1,935 (19.2 percent) participants in the ESA group, respectively, again meeting the trial's prespecified endpoint.

The authors note that the trial had several limitations, including its open-label design, which allowed participants to know the treatment they had been assigned and potentially biasing reporting of adverse events. In addition, while the trial was several years long, HIF-PH inhibitors could have oncogenic or other potential long-term adverse effects, which would need longer term follow-up to detect. The studies focused on the ESAs darbepoetin alfa and epoetin alfa, and findings may not be applicable to other ESAs. But one of the strengths of the trials were their size, which were larger than previous clinical trials of HIF-PH inhibitors with more robust results.

"We found that oral delivery of daprodustat worked just as well as conventional therapy — increasing and maintaining hemoglobin levels among non-dialysis patients and maintaining levels among patients on dialysis — and was just as safe," said Singh. "This could usher in a new way of treating people with kidney disease, avoiding injections while stimulating the body to produce red blood cells."

https://www.nejm.org/doi/10.1056/NEJMoa2113380
hemoglobinoral daprodustatthe new england journal of medicine
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

    Show Full Article
    Next Story

    Editorial

    Dapagliflozin Shines in Post-TAVI Patients:DAPA-TAVI Trial Findings

    Dapagliflozin Shines in Post-TAVI Patients:DAPA-TAVI Trial Findings

    Identifying Candidates for Aspirin in Primary Prevention: Men Aged 40-50 with Hypertension, Dyslipidemia, and Familial ASCVD Risk

    Identifying Candidates for Aspirin in Primary Prevention: Men Aged 40-50 with Hypertension,...

    Featured image representing thinking

    Is Pharma Marketing Going Through "Thinking Recession"?

    Beyond BMI: Why Pioglitazone Deserves a Place in Managing Thin-Fat Type 2 Diabetes in India

    Beyond BMI: Why Pioglitazone Deserves a Place in Managing 'Thin-Fat' Type 2 Diabetes in India

    How to Improve Adherence in Hypertensive Patients? Bridging the Gap with CONNECT Tool

    How to Improve Adherence in Hypertensive Patients? Bridging the Gap with CONNECT Tool

    View All

    Journal Club Today

    Sensitive Skin Explained: Signs, Triggers and Skincare Tips by Dr. Aparajita Lamba

    Sensitive Skin Explained: Signs, Triggers and Skincare Tips by Dr. Aparajita Lamba

    View All

    Health News Today

    Health Bulletin 5/July/ 2025

    Health Bulletin 5/July/ 2025

    View All
    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    X
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok