SGLT2 inhibitor canagliflozin has Heart and kidney benefits among patients across all age categories: Study

Written by Dr Kartikeya Kohli Published On 2024-10-28T20:30:34+05:30 | Updated On 28 Oct 2024 8:31 PM IST

SGLT2 inhibitor canagliflozin has Heart and kidney benefits among patients across all age categories: Study

Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of cardiovascular and kidney outcomes in patients with type 2 diabetes, but it is unclear whether their effects differ based on patients’ age. A recent analysis of clinical trial data reveals that the SGLT2 inhibitor canagliflozin benefited patients across all age categories. The findings will be presented at ASN Kidney Week 2024 October 23-27.

The analysis pooled individual participant data from the CANVAS Program and CREDENCE trial and assessed efficacy and safety according to baseline age. Among the 14,543 participants, 7,927 (54.5%) were <65 years, 5,281 (36.3%) were 65 to <75 years, and 1,335 (9.2%) were ≥75 years.

Across age groups, canagliflozin reduced risks of major adverse cardiovascular events, hospitalization for heart failure or cardiovascular death, and chronic kidney disease progression.

Although the overall incidence of adverse events increased with age, the effects of canagliflozin on safety outcomes including acute kidney injury, volume depletion, urinary tract infections and hypoglycemia, were not modified by age.

“The prevalence of diabetes among older adults aged ≥65 years in the United States is estimated at 29.2%, a prevalence rate more than double that for the overall adult population aged ≥18 years, and older individuals with diabetes have higher absolute risks of cardiovascular events and kidney complications. Despite this, real-world uptake of SGLT2 inhibitors in older age groups is among the lowest of all patient groups,” said corresponding authorAmanda Siriwardana, MBBS (Hon), GCert Public Health, FRACP, of The George Institute for Global Health in Australia. “The data presented in this analysis suggests clear extension of the cardiorenal benefits of SGLT2 therapy to older individuals and should engender confidence amongst clinicians and patients regarding the safety of canagliflozin in older adults.”

Study: “Cardiovascular, kidney and safety outcomes with canagliflozin in older adults: A pooled secondary analysis of the CANVAS Program and CREDENCE trial”

Reference:

Heart and kidney outcomes after canagliflozin treatment in older adults, American Society of Nephrology, Meeting: ASN Kidney Week 2024.

American Society of NephrologyCanagliflozintype 2 diabetesheart failurechronic kidney diseaseacute kidney injury

Dr Kartikeya Kohli

Dr Kartikeya Kohli is an Internal Medicine Consultant at Sitaram Bhartia Hospital in Delhi with super speciality training in Nephrology. He has worked with various eminent hospitals like Indraprastha Apollo Hospital, Sir Gangaram Hospital. He holds an MBBS from Kasturba Medical College Manipal, DNB Internal Medicine, Post Graduate Diploma in Clinical Research and Business Development, Fellow DNB Nephrology, MRCP and ECFMG Certification. He has been closely associated with India Medical Association South Delhi Branch and Delhi Medical Association and has been organising continuing medical education programs on their behalf from time to time. Further he has been contributing medical articles for their newsletters as well. He is also associated with electronic media and TV for conduction and presentation of health programs. He has been associated with Medical Dialogues for last 3 years and contributing articles on regular basis.