Study Finds Significant Link Between Serum Magnesium Levels and Carotid Atherosclerosis in hemodialysis patients
Researchers in a new study have found significant association between serum magnesium (Mg) levels and carotid intima-media thickness (CIMT), suggesting a connection between magnesium levels and carotid atherosclerosis.
They aimed to examine whether serum magnesium level is related to cardiovascular events in hemodialysis patients by investigating the relationship between serum magnesium (Mg) level and carotid intima media thickness (CIMT). In this cross-sectional study, we evaluated 88 hemodialysis patients.
The mean CIMT of these patients was measured and recorded by doppler ultrasonography. Patients were divided into two groups according to their serum magnesium level. Correlation analysis and linear regression analysis were used to define the relationship between study parameters.
We divided our patients into 2 groups according to Mg value as group 1 (Mg ≥ 2.3 mg/dl) and group 2 (Mg < 2.3 mg/dl).
Results: The mean CIMT of patients with group 1 and group 2 were respectively 0.93 ± 0.22 mm and 1.03 ± 0.22 mm. There was statistically significant difference between two groups in terms of the mean CIMT value (p = 0.045). We found negative, low-level, statistically significant correlations between Mg and mean CIMT (r=-0.272; p = 0.010), calcium and mean CIMT (r: -0.221, p: 0.039) and hemoglobin and mean CIMT (r: -0.215, p: 0.044).
According to regression analysis, serum magnesium level and age were found independent risk factors for mean CIMT value (p: 0.004 and p: 0.045). They found a significant relationship between serum Mg level and CIMT, which indicates carotid atherosclerosis.
Reference:
Kara, A.V., Ozdemir, R., Inan, H. et al. Effect of serum magnesium level on carotid intima media thickness in hemodialysis patients. BMC Nephrol 26, 270 (2025). https://doi.org/10.1186/s12882-025-04168-2
