- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Celecoxib Oral Solution Relieves Migraine Pain and Improves Other Symptoms
Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective and widely used for migraine, but gastrointestinal tolerability and safety limit usage by many patients. In a study, researchers have found that celecoxib oral solution is superior to placebo for pain freedom and freedom from the most bothersome symptom when patients treat a migraine attack of any baseline pain intensity. The study findings were published in the Journal of Pain Research on January 16, 2021.
In a previous 2-period, randomized, controlled study, Dr Sagar Munjal and his team evaluated the effect of DFN-15—an oral, ready-made liquid solution of selective cyclo-oxygenase-2 inhibitor celecoxib and placebo for the acute treatment of a moderate-severe migraine attack. In the first treatment period, they found that DFN-15 was superior to placebo on the co-primary efficacy endpoints of pain freedom and other bothersome symptoms. Therefore, they conducted a second treatment period on the same patients by re-randomization and reported the findings.
In the first treatment period, the researchers included a total of 531 adult patients with at least a 1-year history of migraine, including 2 to 8 attacks and no more than 14 headache days per month. The patients were randomly assigned to double-blind trial treatment of attacks of moderate or severe pain with DFN-15,120 mg or placebo. For this present analysis, the researchers re-randomized the 491 patients to either DFN-15 (n=243) or placebo (n=248) to manage an attack of any baseline pain intensity (mild, moderate, or severe). Co-primary efficacy endpoints specified for the first attack were not specified for the second attack.
Key findings of the study were:
- At baseline, the researchers noted that pain intensity was mild in 17.2% (n=85) of patients, moderate in 58.4% (n=288) of patients, and severe in 22.9% (n=113) of patients.
- After 2 hours post-dose, they found that the DFN-15 was superior to placebo for freedom from pain (46.2% vs 31.1%) and the most bothersome symptom (63.4%vs 50.0%).
- They reported a total of 35 Treatment-emergent adverse events (TEAEs), among which 6.1% is from the DFN-15 group and 8% from the placebo group.
- They noted that the study drug-related TEAEs occurred in 5.1% of patients (DFN-15: 4.5% vs placebo 5.6%). The most common adverse events reported were nausea (1%) and dysgeusia (0.8%).
- They reported no serious TEAEs, severe TEAEs, or TEAEs leading to study drug termination.
The authors concluded, "DFN-15 was significantly superior to placebo on multiple efficacy endpoints, including 2-hour freedom from pain and the MBS, as well as headache relief and functional disability. Safety and tolerability results were predictable and similar to placebo."
For further information:
DOI: https://doi.org/10.2147/JPR.S287571
Medical Dialogues Bureau consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers. Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751