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Early cerebral haemorrhage a potential prognostic marker for community-acquired bacterial meningitis
Early cerebral haemorrhage (ECHO) is a potential prognostic marker for community-acquired bacterial meningitis according to a recent study published in the Frontiers in Neurology
Community-acquired bacterial meningitis in adults is associated with significant morbidity and mortality; therefore, early prognostication is important to identify severe cases and possibly allocate more intensive treatment. They hypothesized that early intracranial haemorrhage portends a poor prognosis.
Community-acquired bacterial meningitis is an infectious disease with high rates of morbidity and mortality. In clinical practice, prognostication of neurological outcomes in meningitis is difficult. On one hand, patients who are seemingly hopeless may survive and fully recover. On the other hand, deleterious complications such as stroke, brain edema, or hydrocephalus may occur and worsen outcomes. Large prospective studies set out to identify prognostic factors. As expected, advanced age, signs of more severe neurological affection, and systemic inflammation were prognostic for unfavourable outcomes. Other factors remained equivocal, e.g., both absence and presence of otitis were associated with an unfavourable outcome. While some information is available upon diagnosis, other prognostic factors, such as a positive blood culture or the causative pathogen, are available only during the course of the disease
The objective of this study was to evaluate the prognostic impact of early intracranial haemorrhage regardless of size and location on clinical outcome.
Retrospective analysis of patients with community-acquired bacterial meningitis treated at a tertiary academic centre between 2009 and 2019 about patient characteristics, cerebral imaging findings, and clinical outcome. Uni- and multivariable logistic regression analyses were performed to identify independent predictors of poor clinical outcomes defined as a modified Rankin scale score of 5 or 6 upon discharge.
Results:
A total of 102 patients were included, of which 22.5% had poor clinical outcomes. Intracranial micro- or macrohemorrhages were present in 7.8% of cases and associated with poor clinical outcomes in multivariate analysis, further predictors included ischemic stroke, age, and reduced consciousness
Thus, early cerebral haemorrhage (ECHO) is a potential prognostic marker for clinicians confronted with decision-making in patients who are critically ill with community-acquired bacterial meningitis.
Reference:
Weller Johannes, Enkirch Jonas Simon, Lehmann Felix, Radbruch Alexander, Klockgether Thomas, Zimmermann Julian. Early Intracranial Hemorrhage Predicts Poor Clinical Outcome in Community-Acquired Bacterial Meningitis. Frontiers in Neurology. VOLUME=13.2002. https://www.frontiersin.org/articles/10.3389/fneur.2022.869716. DOI=10.3389/fneur.2022.869716
Keywords:
Early, Intracranial, Hemorrhage, Predicts, Poor, Clinical, Outcome, Community, Acquired, Bacterial, Meningitis, Johannes Weller, Jonas Simon Enkirch, Felix Lehmann, Alexander Radbruch, Thomas Klockgether, Julian Zimmermann, Frontiers in Neurology
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751