- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Higher Genetically Influenced Lean Muscle Mass Lowers Alzheimer's Disease Risk by 12%.
![Higher Genetically Influenced Lean Muscle Mass Lowers Alzheimers Disease Risk by 12%. Higher Genetically Influenced Lean Muscle Mass Lowers Alzheimers Disease Risk by 12%.](https://medicaldialogues.in/h-upload/2023/07/05/750x450_213621-untitled-design-2023-07-05t210755883.webp)
A study published in BMJ Medicine entitled "Genetically proxied lean mass and risk of Alzheimer's disease: mendelian randomisation study" has concluded that the study's findings indicate that genetically proxied lean mass could potentially serve as a protective factor against Alzheimer's disease.
The main objective of this study was to examine whether genetically proxied lean mass is associated with Alzheimer's disease risk.
The study design was a Mendelian randomisation study.
The Setting was a UK Biobank and genome-wide association study meta-analyses of Alzheimer's disease and cognitive performance.
The data on study participants include:
- UK Biobank participants included data from 450,243 individuals who had lean and fat mass measurements.
- Alzheimer's disease patients and controls: Data from an independent group of 21,982 patients with Alzheimer's disease and 41,944 controls (individuals without Alzheimer's disease).
- Replication sample: Data from 7,329 Alzheimer's disease patients and 252,879 controls.
- Cognitive performance: 269 867 individuals taking part in a genome-wide association study.
They measured the main outcome as the Effect of genetically proxied lean mass on the risk of Alzheimer's disease and the related phenotype of cognitive performance.
The study results could be summarised as follows:
- An increase in genetically proxied appendicular lean mass reduced the risk of Alzheimer's disease by 12 %.
- Higher genetically proxied appendicular lean mass had an association with increased cognitive performance, and adjusting for potential mediation through genetically proxied cognitive performance did not reduce the association between appendicular lean mass and Alzheimer's disease risk.
Based on these findings, they concluded that lean mass may be a possible modifiable protective factor for Alzheimer's disease. Further investigations are warranted for mechanisms underlying this finding and the clinical and public health implications.
Further reading:
BDS, MDS in Periodontics and Implantology
Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751