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Higher hs-CRP to HDL-C ratio associated with adverse outcomes in ischaemic stroke patients, finds study
A new study published in the journal of BMC Neurology showed that an elevated high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratio (hs-CRP/HDL-C ratio) considerably raised the risk of bad outcomes in individuals who had an acute ischemic stroke (AIS), where each unit increase was associated with a 2.4% higher chance of adverse outcomes.
According to recent Global Burden of Disease (GBD) data, stroke mortality, incidence, and disability-adjusted life years (DALYs) decreased between 1999 and 202. It is currently unknown if blood high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratios are associated with outcomes in individuals with acute ischemic stroke.
Data from a prospective cohort study including 1559 AIS patients who were enrolled at a South Korean hospital between January 2010 and December 2016 were used in this secondary analysis. To investigate the relationship between the hs-CRP/HDL-C ratio and adverse outcomes in AIS patients, this study built a binary logistic regression model. To clarify possible nonlinear interactions, a generalized additive model (GAM) with smooth curve fitting was attempted. Also, binary logistic regression models were created for either side of the inflection points, which were found using a recursive technique. The best model for elucidating the relationship between the hs-CRP/HDL-C ratio and adverse outcomes in patients with AIS was ultimately determined using a log-likelihood ratio test.
The outcomes suggested that the median hs-CRP/HDL-C ratio was 3.64, and the incidence of adverse events was 24.5%. A statistically significant positive correlation between the hs-CRP/HDL-C ratio and the probability of poor outcomes in AIS patients was found using the binary logistic regression model after controlling for other variables. With the hs-CRP/HDL-C ratio's initial inflection point at 42.74, a nonlinear connection was noted. A 2.4% higher chance of adverse outcomes was linked to every unit rise in the hs-CRP/HDL-C ratio.
Overall, the hs-CRP/HDL-C ratio and 3-month adverse outcomes in AIS patients were shown to be positively and nonlinearly correlated in this study. A substantial positive correlation between rising ratios and worse outcomes in AIS patients was identified when the hs-CRP/HDL-C ratio was ≤42.74. Thus, the hs-CRP/HDL-C ratio may be a practical and affordable predictive biomarker that predicts negative results in AIS patients.
Source:
Luwen, H., Lei, X., Qing-Rong, O., Linlin, L., & Ming, Y. (2024). Association between hs-CRP/HDL-C ratio and three-month unfavorable outcomes in patients with acute ischemic stroke: a second analysis based on a prospective cohort study. In BMC Neurology (Vol. 24, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12883-024-03929-0
Neuroscience Masters graduate
Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751