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  • Keto-Diet, A Better...

Keto-Diet, A Better Nutritional Approach for MS Patients

Written By : MD Bureau |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-05-02T10:30:13+05:30  |  Updated On 2 May 2022 2:24 PM IST
Keto-Diet, A Better Nutritional Approach for MS Patients
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Obesity is a recognized risk factor for multiple sclerosis (MS) and, dietary intake is one potentially modifiable environmental contributor to MS has garnered much interest from people living with MS. A recent study suggests that the ketogenic diet (KD) is safe and beneficial in reducing a few symptoms for people with MS when used for over 6 months.

The study findings were published in the Journal of Neurology, Neurosurgery & Psychiatry on 13 April 2022.

KDs are high-fat, low-carbohydrate diets that mimic a fasting state. KDs, in particular, may alter key aspects of MS pathogenesis via ketosis-induced upregulation of antioxidant pathways, reduced effector cell immunity, and enhanced CNS bioenergetics, which may provide an alternative energy source to vulnerable neurons. To further explore, Dr J Nicholas Brenton and his team conducted a study to assess the tolerability of a ketogenic diet in patients with relapsing multiple sclerosis and define the impact on laboratory and clinical outcome metrics.

In this prospective, intention-to-treat KD intervention, the researchers included sixty-five patients with relapsing MS and followed them for 6-months. They monitored adherence with daily urine ketone testing. At baseline, fatigue, depression and quality of life (QoL) scores were obtained in addition to fasting adipokines and MS-related clinical outcome metrics. They further repeated the baseline metrics at 3 and/or 6 months on diet.

Key findings of the study:

  • Upon analysis, the researchers found that the patients exhibited significant reductions in fat mass and showed a nearly 50% decline in self-reported fatigue and depression scores.
  • They also found that MS QoL physical health (67±16 vs 79±12) and mental health (71±17 vs 82±11) composite scores increased on diet.
  • They noted significant improvements in Expanded Disability Status Scale scores (2.3±0.9 vs 1.9±1.1), 6-minute walk (1631±302 vs 1733±330 ft) and Nine-Hole Peg Test (21.5±3.6 vs 20.3±3.7 s).
  • They further noted that serum leptin was lower (25.5±15.7 vs 14.0±11.7 ng/mL) and adiponectin was higher (11.4±7.8 vs 13.5±8.4 µg/mL) on the KD.

The authors concluded, "KDs are safe and tolerable over a 6-month study period and yield improvements in body composition, fatigue, depression, QoL, neurological disability and adipose-related inflammation in persons living with relapsing MS".

For further information:

DOI: http://dx.doi.org/10.1136/jnnp-2022-329074


Ketogenic dietmultiple sclerosisfatiguedepressionquality of lifeneurological disabilityQoLrelapsing MSMSdaily urine ketone testJournal of NeurologyNeurosurgery & Psychiatry
Article Source :  Journal of Neurology, Neurosurgery & Psychiatry
MD Bureau
MD Bureau

    Medical Dialogues Bureau consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers.  Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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