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  • Patients with renal...

Patients with renal impairment more likely to suffer from cardioembolic stroke later

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-03-17T09:00:48+05:30  |  Updated On 17 March 2022 9:00 AM IST
Patients with renal impairment more likely to suffer from cardioembolic stroke later
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Osaka, Japan - "The foot bone's connected to the ankle bone," goes the schoolyard song, highlighting the ways in which each part of our body can affect other parts of the body. Now, researchers from Japan have found that the kidney is connected to the heart, in that kidney malfunction is associated with different types of stroke.

In a study published March, in Neurology, researchers from the National Cerebral and Cardiovascular Center of Japan (Kinya Otsu, President) found that patients showing indicators of poor kidney function are more likely to suffer a cardioembolic stroke but less likely to experience small vessel occlusion than patients with normal kidney function.

Chronic kidney disease has a known link to stroke, as patients with impaired kidney function are twice as likely as healthy individuals to suffer from a stroke. There are several different kinds of stroke, however, and it's unclear whether poor kidney health makes people more susceptible to all types of stroke or favors certain types.

"Other groups have explored the link between renal impairment and stroke," explains Kaori Miwa, lead author, on behalf of the Japan Stroke Data Bank Investigators. "But the results were inconsistent, with some studies finding no significant association between these two conditions, and some studies showing that there is indeed a connection."

To resolve this controversy, the researchers analyzed clinical data from over 10,000 individuals from the Japan Stroke Data Bank, a nationwide database of patients with acute stroke. This multicenter hospital-based registry has the advantages of including standardized clinical information, ensuring a valid diagnosis of stroke, and involving acute management by stroke specialists.

"Using such a large and comprehensive database enabled us to definitively show that low filtration rates and high levels of protein in the urine are associated with cardioembolic stroke, while small vessel occlusion was less common compared to other types of stroke," states Masatoshi Koga, second author on the paper.

In addition to the increased risk of cardioembolic stroke, low filtration rate predicted a disability after cardioembolic stroke, and both low filtration rate and high urine protein levels were linked to a greater chance of dying during hospitalization for stroke.

"Our findings conclusively show that there is a statistically significant association between renal impairment and clinical outcomes after specific ischemic stroke subtypes," states Kazunori Toyoda, senior author on the paper.

Given that almost 10% of the worldwide population suffers from chronic kidney disease, the insights provided by this large-scale study could help predict the risk of stroke and the ultimate prognosis in many of these patients. Understanding what subtype of stroke patients with impaired kidney function are likely to undergo may be useful for guiding preventive treatment.

https://n.neurology.org/content/early/2022/03/08/WNL.0000000000200153

Kinya Otsu,cardioembolic stroke,Japan Stroke Data Bank Investigators,Masatoshi Koga,chronic kidney disease,neurology,renal impairment,heart disease,heart attack,

urinekidneyheartneurology
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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