Statin adherence reduces risk of ischemic and hemorrhagic stroke: Study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-12-21T11:15:47+05:30 | Updated On 21 Dec 2021 2:30 PM IST

A significant association exists between statin adherence and ischemic and hemorrhagic stroke risk, hence it is necessary to stick to statin therapy, according to a recent study published in the Nutrition, Metabolism and Cardiovascular Diseases.

The effectiveness of statins commonly used to prevent a stroke may depend on adherence to treatment. The researchers examined the association between statin adherence and stroke risk among South Korean adults with hyperlipidemia.

The data of 128,052 and 129,390 participants with hyperlipidemia for studying the risks of ischemic and hemorrhagic stroke, respectively, were collected from the Korean National Health Insurance Service-National Sample Cohort between 2002 and 2013. Participants were divided into groups according to statin adherence, calculated as the proportion of days covered (PDC; poor, moderate, good). The risk of ischemic and hemorrhagic stroke was analyzed using a Cox proportional hazards model.

The results of the study are as follows:

Individuals with poor PDC exhibited higher risks of ischemic and hemorrhagic stroke than those with good PDC (ischemic stroke: hazard ratio [HR]=1.09, 95% confidence interval [CI] =1.03–1.15, hemorrhagic stroke: HR=1.37, 95% CI=1.22–1.54). Women with poor PDC were at higher risk of ischemic stroke than those with good PDC (HR=1.17, 95% CI=1.09–1.26), while men with poor PDC exhibited a higher risk of hemorrhagic stroke than those with good PDC (HR=1.55, 95% CI=1.27–1.90). Individuals with disabilities who had poor PDC were at higher risk of ischemic stroke than those with good PDC (HR=1.55, 95% CI=1.24–1.93).

Thus, the researchers concluded that they detected a significant association between statin adherence and ischemic and hemorrhagic stroke risk. Therefore, hyperlipidemia patients should adhere to statin treatment; such interventions are required to reduce the stroke risk.

Reference:

Association between statin adherence and the risk of stroke among South Korean adults with hyperlipidemia by Wonjeong Jeong et al. published in the Nutrition, Metabolism and Cardiovascular Diseases.

https://www.nmcd-journal.com/article/S0939-4753(21)00569-X/fulltext?rss=yes

statin adherencehemorrhagic strokeIschemic strokerisk factorsassociationnutritionnmcd journalhyperlipidemiausual provider continuity indexproportion of days covered

Source : Nutrition, Metabolism and Cardiovascular Diseases

Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751