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  • ICMR study to evaluate...

ICMR study to evaluate efficacy of shorter 4-month tuberculosis treatment regimen

Medical Dialogues BureauWritten by Medical Dialogues Bureau Published On 2022-07-05T16:30:18+05:30  |  Updated On 5 July 2022 4:30 PM IST
ICMR study to evaluate efficacy of shorter 4-month tuberculosis treatment regimen
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As a part of the study around 550 tuberculosis (TB) patients will be recruited who will be getting the four-month treatment regimen, the regular Fixed-dose Combination (FDC) with Moxifloxacin added to it.

Chennai: ICMR's National Institute for Research in Tuberculosis has initiated a study to assess the efficacy of a four-month tuberculosis treatment regimen as compared to the existing six-month regimen.

The trial study is being conducted at five sites — Indira Gandhi Government Medical College and Hospital (IGGMCH) in Nagpur; King George's Medical University, Lucknow; Mahavir Hospital and Research Centre, Hyderabad; Government Vellore Medical College and Hospital, Adukkamparai; and Lok Nayak Hospital, New Delhi.

Also Read:Higher COVID risk for unvaccinated with liver, weight issues: ICMR

The study is being funded by the Indian Council of Medical Research (ICMR).

"As a part of the study, we will be recruiting around 550 tuberculosis (TB) patients who will be getting the four-month treatment regimen, the regular Fixed-dose Combination (FDC) with Moxifloxacin added on to it. We will follow them for relapse for 24 months post treatment," Dr Padma Priyadarshini, Director, ICMR's National Institute for Research in Tuberculosis (NIRT) said.

The enrolment is underway at the sites. Delhi and Lucknow sites have started recruiting, while the other sites will be starting soon, she said.

We hope to complete the enrolment by August and follow them up for two years to know the results of whether this shorter treatment works or not. We just have to increase the pace of recruitment in all the sites, she said.

The whole idea of shortening the treatment does just not cure, but to see that the patients do not have a recurrence of the disease. That is the principle of shortening treatment, Dr Priyadarshini said.

"At present, we are doing the study among adults. We will be following the patients for at least two years and see the occurrence of TB among these patients. Based on the study results, we can then advocate it for every age group," she said.

The four-month daily regimen containing Moxifloxacin of ICMR-NIRT was studied in 321 sputum-positive pulmonary TB patients in a randomised clinical trial in Tamil Nadu a couple of years ago.

Now based on the successful result from that trial, we have upscaled it across the country in five sites, she said.

Under the National Tuberculosis Elimination Programme (NTEP), anti-TB drugs are offered as fixed dose combinations (FDC).

Also Read:Serum Institute of India gets DCGI nod for skin test kit for latent TB diagnosis

National Institute for Research in Tuberculosistuberculosis treatmentIndian Council of Medical ResearchICMRtuberculosisIndira Gandhi Government Medical College and HospitalKing Georges Medical UniversityMahavir Hospital and Research CentreGovernment Vellore Medical College and HospitalLok Nayak HospitalTB patients
Source : PTI
Medical Dialogues Bureau
Medical Dialogues Bureau

    Medical Dialogues Bureau consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers.  Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.

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