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  • AstraZeneca closes...

AstraZeneca closes Eplontersen agreement with Ionis

Medical Dialogues BureauWritten by Medical Dialogues Bureau Published On 2022-01-02T10:00:21+05:30  |  Updated On 2 Jan 2022 10:00 AM IST
AstraZeneca discontinues Phase 3 trial of prostate cancer drug Truqap
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UK: AstraZeneca has announced that the company has closed a global development and commercialisation agreement with Ionis Pharmaceuticals, Inc. for eplontersen, formerly known as IONIS-TTR-L.

The companies will jointly develop and commercialise eplontersen in the US, while AstraZeneca will develop and commercialise it in the rest of the world, except in Latin America.

Under the terms of the agreement, the upfront payment from AstraZeneca to Ionis is $200m. AstraZeneca will make additional conditional payments of up to $485m following regulatory approvals. It will also pay up to $2.9bn of sales-related milestones based on sales thresholds between $500m and $6bn, plus royalties in the range of low double-digit to mid-twenties percentage depending on the region. The collaboration includes territory-specific development, commercial and medical affairs cost-sharing provisions.

The transaction will be funded with cash and is expected to be neutral to Core earnings in 2021. It will be accounted for as an intangible asset acquisition, recognised initially at the upfront amount, with any potential future milestone payments capitalised into the intangible asset as they are recognised.

Ionis will continue to manufacture and supply eplontersen for the existing clinical studies and process qualification. AstraZeneca will be responsible for commercial supply, with transition timing to be agreed by both parties. AstraZeneca will book all sales generated under the agreement.

Read also: AstraZeneca, Make-A-Wish foundation join hands to aid children suffering from critical ailments

The transaction does not impact AstraZeneca's financial guidance for 2021.

Eplontersen is a ligand-conjugated antisense (LICA) investigational medicine designed to reduce the production of transthyretin, or TTR protein, to treat all types of TTR amyloidosis (ATTR), a systemic, progressive and fatal disease.

AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology.

Read also: AstraZeneca to study cancer drug Datopotamab deruxtecan in India

fatal diseaseeplontersenIONIS-TTR-Lastrazenecaastrazeneca newsionis pharma
Medical Dialogues Bureau
Medical Dialogues Bureau

    Medical Dialogues Bureau consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers.  Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.

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