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Emcure Pharma arm Gennova advances development of Nipah virus vaccine

Pune: Emcure Pharmaceuticals Ltd. subsidiary Gennova Biopharmaceuticals Ltd., is advancing the development of a pathbreaking self-amplifying mRNA (saRNA) vaccine against the deadly Nipah virus.
This critical initiative is supported by an expanded partnership with the Coalition for Epidemic Preparedness Innovations (CEPI), with funding of up to US$13.38 million. Gennova will also team up with US-based Houston Methodist Research Institute (HMRI), also a CEPI partner, to use their cutting-edge AI technology to optimize the properties of proteins derived from the virus that could stimulate the immune system and serve as optimal vaccine targets for Gennova to investigate in the lab and in the clinic.
Nipah virus belongs to the Paramyxovirus family. It is one of the deadliest pathogens known to infect humans. So far, Nipah outbreaks have been confined to South and Southeast Asia, but the fruit-bat vector is found in large geographical areas across the globe covering a population of more than 2 billion people.
“With no vaccines or specific therapeutics approved for human use against Nipah, CEPI is leading the charge to protect the world against this deadly virus committing over US$100 million to its Nipah programmes and advancing the first ever Nipah vaccine candidates into Phase 1 studies and through to completion”, said Dr Kent Kester, Executive Director of Vaccine Research and Development at CEPI. “Gennova’s work will not only help establish the suitability of the saRNA platform for use against Nipah but also its suitability as part of a wider group of RNA technologies that could enable rapid responses to future Disease X threats, potentially within 100 days of identification.”
mRNA vaccines use the body's own machinery to make antigenic protein rather than injecting the antigen directly into the body. saRNA vaccines work by giving the body instructions to replicate mRNA needed to create the desired antigen, potentially enhancing the immune response with lower doses compared to existing mRNA vaccines.
In August 2023, CEPI initially provided up to $3.6 million to support the optimisation of Gennova’s saRNA-platform technology to develop vaccine candidates against unknown pathogenic threats, also referred to as Disease X. The initial tranche of funding was part of CEPI's programme to support novel RNA vaccine platform technologies for emerging and select endemic infectious diseases, which could offer substantial advantages over existing mRNA technologies, such as multivalency, improved immunogenicity, storage and stability, productivity, response time, and cost-of-goods.
Dr. Sanjay Singh, CEO of Gennova Biopharmaceuticals Limited, shared optimism about the collaboration with CEPI and HMRI, viewing it as a significant advancement in the fight against the Nipah virus.
“By harnessing the cutting-edge capabilities of our saRNA platform, we are committed to developing a revolutionary next-generation vaccine. This partnership not only sets a new standard for the rapid development of mRNA vaccines but also ensures equitable access and strengthens global health security”, said Singh.
"CEPI is committed to enabling equitable access to the vaccines, products and innovations it supports. Through its agreement to enter into partnership with CEPI, Gennova has demonstrated its shared commitment to ensuring equitable access to its technology in line with CEPI’s Equitable Access Policy, notably committing to vaccines being available first to populations at risk when and where they are needed at an affordable price. This also includes the potential application of its technology to future vaccine development of interest to CEPI, including a commitment to technology transfer," the Company stated in a release.
Ruchika Sharma joined Medical Dialogue as an Correspondent for the Business Section in 2019. She covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She has completed her B.Com from Delhi University and then pursued postgraduation in M.Com. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751