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  • Merck, Eisai to shut...

Merck, Eisai to shut down late stage study for combo cancer therapy

Ruchika SharmaWritten by Ruchika Sharma Published On 2023-08-28T12:31:14+05:30  |  Updated On 28 Aug 2023 12:31 PM IST
Merck gets USFDA Priority Review for application for Keytruda plus standard of care as Perioperative treatment for Resectable Locally Advanced Head, Neck Squamous Cell Carcinoma
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The companies are testing the combination to treat a range of cancers, including those affecting the lungs and stomach.

Kenilworth: Merck & Co and partner Eisai have said they will shut down a late-stage study testing an experimental combination therapy for a type of head and neck cancer after an interim analysis showed it failed to prolong lives of patients.

The therapy, Merck's blockbuster drug Keytruda in combination with Eisai's Lenvima, failed to show statistical significance in extending overall survival, one of the three main goals of the study, the companies said.

The companies were testing the combination for head and neck squamous cell carcinoma — a cancer that develops in the mucous membranes of the mouth, nose and throat — in patients with recurrent or metastatic form of the disease and whose tumors contain a protein called PD-L1.

This type of cancer is especially common in parts of Southeast Asia, and the companies estimate it to lead to more than 66,000 new diagnoses in the United States this year.

Read also: Merck declares topline results from Phase 3 trial of Welirag

"Our clinical program is designed to help accelerate our efforts to tackle difficult-to-treat, advanced cancers, and while the outcome may not always be what we anticipate, we know that this is part of clinical development," said Eisai executive Corina Dutcus.

The therapy met other main goals of reducing tumor size and improving the time to death or disease worsening after treatment compared to placebo.

Read also: Merck Ervebo gets USFDA nod for prevention of disease caused by Zaire ebolavirus in children aged 12 months and older

The companies are testing the combination to treat a range of cancers, including those affecting the lungs and stomach.

The Keytruda-Lenvima combination therapy is approved in the United States for the treatment of a type of kidney cancer and certain types of cancers in the lining of the uterus.

Read also: Setback: Merck, Eisai to stop late-stage study of Keytruda plus Lenvima for metastatic melanoma

merckmerck newseisaieisai newsneck cancerhead cancerKeytrudaLenvima
Source : Reuters
Ruchika Sharma
Ruchika Sharma

    Ruchika Sharma joined Medical Dialogue as an Correspondent for the Business Section in 2019. She covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She has completed her B.Com from Delhi University and then pursued postgraduation in M.Com. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751

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