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  • Moderna, Merck cancer...

Moderna, Merck cancer vaccine plus Keytruda delays skin cancer return

Ruchika SharmaWritten by Ruchika Sharma Published On 2023-04-17T15:59:25+05:30  |  Updated On 14 Feb 2024 12:05 AM IST
Moderna, Merck cancer vaccine plus Keytruda delays skin cancer return
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The vaccine is custom-built based on an analysis of a patient's tumors after surgical removal.

New Delhi: An experimental mRNA cancer vaccine developed by Moderna Inc and Merck & Co cut the risk of death or recurrence of the most deadly skin cancer by 44 percent compared with Merck's immunotherapy Keytruda alone, U.S. researchers reported at a medical meeting on Sunday.

The findings suggest that adding a personalized cancer vaccine based on mRNA technology to Keytruda, which revs up the immune response, could prolong the time patients have without recurrence or death, said Dr Jeffrey Weber, NYU Langone Perlmutter Cancer Center, who presented the findings.
"From a general cancer therapeutic standpoint, this is a potential major breakthrough," Dr Ryan Sullivan, melanoma expert, Mass General Cancer who worked on the study, said in a statement.
The results, presented at American Association for Cancer Research meeting in Orlando, Florida, add data details to partial findings released by the companies in December.
The Merck/Moderna collaboration is one of several combining powerful drugs that unleash the immune system to target cancers with mRNA vaccine technology. BioNTech SE and Gritstone Bio Inc are working on competing cancer vaccines based on mRNA technology.
The vaccine is custom-built based on an analysis of a patient's tumors after surgical removal. The vaccines are designed to train the immune system to recognize and attack specific mutations in cancer cells.
Merck's Keytruda, which is approved to treat melanoma and many other cancers, belongs to a class of widely used immunotherapies known as checkpoint inhibitors designed to disable the PD-1, or programmed death 1, protein that helps cancer evade the immune system.
The midstage trial enrolled men and women at high risk of their melanoma returning.
Among 107 study subjects who received both the experimental vaccine, mRNA-4157/V940, and Keytruda, the cancer returned in 24 subjects (22.4 percent) within two years of follow-up, compared with 20 out of 50 (40 percent) who received Keytruda alone.
There was little difference in response rates among people whose tumors had a lot of mutations - a typical predictor of immunotherapy response - and those whose tumors did not.
Severe side effects were similar between the two arms of the study, the scientists reported. Fatigue was the most common side effect reported by patients specifically associated with the vaccine.
Merck said the companies are in talks with U.S. regulators about design of a late-stage trial, which is likely needed for approval of the combination regimen.
It could take three or four years before the results of the larger trials are known, Eliav Barr, Merck's head of global clinical development and chief medical officer, said in an interview.
Barr said it took about eight weeks to design a personalized mRNA vaccine for each patient.
In the past, similar experimental cancer vaccines were developed targeting a single tumor mutation, or neoantigen.
Moderna's mRNA technology allowed for the inclusion of as many as 34 neoantigens, which Barr called 'astonishing.'
Currently, scientists cannot predict which single mutation is important in generating an anti-tumor response. With mRNA technology in combination with Keytruda, "we can create this shotgun approach that can create a more potent immune response," Barr said.
Read also: Merck, Moderna get PRIME scheme designation from EMA for personalized mRNA cancer vaccine, KEYTRUDA combo for adjuvant treatment of High-risk Melanoma
modernamerckskin cancerKeytruda
Source : Reuters
Ruchika Sharma
Ruchika Sharma

    Ruchika Sharma joined Medical Dialogue as an Correspondent for the Business Section in 2019. She covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She has completed her B.Com from Delhi University and then pursued postgraduation in M.Com. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751

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