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Sun Pharma discontinues development of skin disease drug after trials failure

Written By : Ruchika Sharma |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-06-04T12:27:55+05:30  |  Updated On 4 Jun 2025 12:57 PM IST
Sun Pharma discontinues development of skin disease drug after trial dissapointment
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Mumbai: Sun Pharmaceutical Industries Limited has announced the discontinuation of two clinical trials evaluating SCD-044, a novel, orally bioavailable sphingosine-1- phosphate (S1P) receptor 1 agonist, for moderate to severe psoriasis and atopic dermatitis.

This came after top-line results from the Phase 2 clinical trial did not meet its primary endpoint of 75% improvement in PASI (Psoriasis Area and Severity Index) score (≥PASI75) and EASI (Eczema Area and Severity Index) score (≥EASI75) at Week 16.

The Phase 2 randomized, double-blind, placebo-controlled study of SCD-044 included 263 people living with moderate to severe plaque psoriasis. The Phase 2 atopic dermatitis study of SCD-044 included 250 people and compared three different dosages of SCD-044 with placebo.

Read also: Sun Pharma promotes Bhaskar Dharival as General Manager and Head HR and Administration

"Sun Pharma is discontinuing clinical trials of the asset and has no further plans for development of SCD-044. Sun Pharma and its partner, Sun Pharma Advanced Research Company Ltd., will evaluate the appropriate next steps for SCD-044," the release stated.

“While we are disappointed with the top-line results of the clinical trials, we would like to thank all the psoriasis and atopic dermatitis patients, the healthcare professionals and administrators who participated in these pivotal clinical trials,” said Marek Honczarenko, MD, PhD, Senior Vice President and Head of Global Specialty Development at Sun Pharma.

Read also: Sun Pharma-Moebius Medical announce dual publications on symptomatic knee osteoarthritis treatment MM-II in Osteoarthritis and Cartilage

There were no major safety or tolerability concerns with SCD-044 in either the plaque psoriasis or atopic dermatitis studies.

Sun Pharma is a specialty generics company with a presence in specialty, generics and consumer healthcare products. Sun Pharma’s global specialty portfolio spans innovative products in dermatology, ophthalmology, and onco-dermatology and accounts for over 18% of company sales. Its manufacturing facilities are spread across six continents.

Read also: Sun Pharma scores USFDA nod for Next Generation BLU-U Blue Light Photodynamic Therapy Illuminator for Actinic Keratosis

sun pharmasun pharma newspsoriasisSCD 044atopic dermatitis
Ruchika Sharma
Ruchika Sharma

    Ruchika Sharma joined Medical Dialogue as an Correspondent for the Business Section in 2019. She covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She has completed her B.Com from Delhi University and then pursued postgraduation in M.Com. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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