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  • Elagolix may help...

Elagolix may help reduce heavy bleeding in fibroids: NEJM

Dr. Kamal Kant KohliWritten by Dr. Kamal Kant Kohli Published On 2020-01-24T16:01:50+05:30  |  Updated On 24 Jan 2020 10:31 AM GMT
Elagolix may help reduce heavy bleeding in fibroids: NEJM

PHILADELPHIA - About 50 % of women with uterine fibroids-experience heavy menstrual bleeding and other symptoms. Thes women with fibroids with severe symptoms like bleeding have a comparatively compromised quality of life. Surgery and long-acting injectable medications are acceptable treatments for many, but certainly not all women in this situation as they have their own side effects....

PHILADELPHIA - About 50 % of women with uterine fibroids-experience heavy menstrual bleeding and other symptoms. Thes women with fibroids with severe symptoms like bleeding have a comparatively compromised quality of life. Surgery and long-acting injectable medications are acceptable treatments for many, but certainly not all women in this situation as they have their own side effects. Heartening news for such patients.

Researchers have reported on the effectiveness of a new, rapidly reversible oral pill elagolix that was used to reduce heavy menstrual bleeding in women with uterine fibroids.

The study was conducted by a large group of researchers from across the country and was led by Dr. William Schlaff, Chair of the Department of Obstetrics and Gynecology at the Sidney Kimmel Medical College at Thomas Jefferson University.

The study has been published in the New England Journal of Medicine.

A total of 790 women, ages 18-51, with heavy bleeding due to fibroids, were enrolled in one of three study arms. One group received the oral pill, elagolix, which reduces the production of the hormones estrogen and progesterone normally produced by a woman's ovaries. When these hormones are suppressed, fibroids usually get smaller and bleeding is reduced. A second group received elagolix plus a low dose of estrogen and progestin ("add-back" therapy) with the hope that the additional hormones would produce the same benefit but reduce the side effects of elagolix used alone (like hot flushes and bone loss). A third group received identical placebo pills that did not contain elagolix or the "add-back" hormones. All of the women enrolled in the two identical trials reported by these researchers were confirmed to have uterine fibroids by ultrasound and heavy menstrual bleeding (more than 80mLs of blood loss per cycle) for at least two cycles.

The results showed that 80.4% of the women treated with elagolix alone had a reduction of menstrual bleeding of 50% or more compared to 9.6% of the women in the placebo group. Of those women treated with elagolix plus "add-back" therapy, 72% had a reduction of 50% or more. Women treated with elagolix alone had significantly more loss of bone mineral as compared with the women treated with placebo, a known and clinically significant side effect of this class of medications. However, there was no difference between the loss of bone mineral in the group treated with elagolix and "add-back" as compared to those in the placebo group.

"The potential value of an oral, easily reversible medication that can be combined with low-dose hormonal "add-back" to reduce heavy menstrual bleeding while avoiding problematic symptoms and side effects could be a major step forward," says Dr. Schlaff.

For further reference log on to:

Article reference: William Schlaff et al., "Elagolix Therapy for Heavy Menstrual Bleeding in Women with Uterine Fibroids," New England Journal of Medicine, DOI: 10.1056/NEJMoa1904351, 2019. 

Elagolix NEJM New England Journal of Medicine Fibroids heavy menstrual bleeding 
Source : New England Journal of Medicine
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Before Joining Medical Dialogues, he has served at important positions in the medical industry in India including as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils in India. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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