CKD stage 3b-5 and proteinuria in pregnancy may worsen renal and maternal outcomes

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-09-22T20:30:21+05:30 | Updated On 22 Sept 2022 8:30 PM IST

China: Chronic kidney disease (CKD) stage 3b-5 and proteinuria during early pregnancy predict adverse obstetric and renal outcomes, says a new study published in Pregnancy Hypertension.

The study found that pregnancy outcomes of patients with proteinuria less than 1 g/24 h and stage 3a CKD to be acceptable. And, pregnancy accelerates the deterioration of renal function more significantly in patients with stage 3-5 CKD and urinary protein concentrations above 1 g/24 h.

The study was conducted by Yingdong He, Department of Obstetrics and Gynecology, Peking University, First Hospital, Beijing, PR, China, and colleagues to examine pregnancy outcomes and the effects of pregnancy on kidney function in patients with stage 3-5 chronic kidney disease in a retrospective study.

For this purpose, the researchers analyzed clinical data of women with pregnancies complicated by stage 3-5 CKD who did their delivery in the Peking University First Hospital from January 1st, 2013, to December 31st, 2020. A total of difty-three patients with 54 pregnancies were studied.

The study led to the following findings:

The mean levels of serum creatinine and eGFR in the first trimester were 138.4±76.7 umol/l and 44.9±13.5 ml/min/1.73m², respectively. The perinatal mortality rate was 1.92%.
The mean gestational age at birth was 35.4 weeks, and the average infant birth weight was 2333 g.
The average gestational week at delivery of patients with stage 3a CKD was 36.8±2.1 weeks and there were no adverse neonatal outcomes.
Compared with that in early pregnancy, the mean eGFR at 6 months after delivery decreased (52.3±7.3 vs 44.8±10.5 ml/min per 1.73m²) in patients with stage 3a CKD and urine protein≥1 g/24 h and in patients with stage 3b CKD and urine protein≥1 g/24 h (38.0±2.7 vs. 26.9±10.1 ml/min per 1.73m²).

The authors concluded their study by saying that, "CKD stage 3b-5 and proteinuria in early pregnancy are important predictors of adverse obstetric and renal outcomes."

Reference:

The study titled, "Pregnancy in patients with stage 3-5 CKD: maternal and fetal outcomes," appears in the journal Pregnancy Hypertension. DOI: https://doi.org/10.1016/j.preghy.2022.06.005

Pregnancy Hypertensionproteinuriachronic kidney diseaseearly pregnancy

Source : Pregnancy Hypertension

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751