Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • Medical Jobs
  • Medical Matrimony
  • MD Brand Connect
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • MCI News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Aborad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • MCI News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Obstetrics and Gynaecology
  • Obstetrics and Gynaecology News
  • Exercise precaution...

Exercise precaution while using paracetamol during pregnancy: Consensus statement

MD Editorial TeamWritten by MD Editorial Team Published On 2021-09-29T09:00:21+05:30  |  Updated On 29 Sep 2021 5:25 AM GMT
Exercise precaution while using paracetamol during pregnancy: Consensus statement
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • koo
  • Email

USA: A Consensus Statement was issued to focus research activities and give evidence-based medical recommendations for pregnant women who take Paracetamol (N-acetyl-p-aminophenol (APAP). The study's findings suggest that pregnant women should take APAP with caution and for the least amount of time feasible. Long-term or high-dose usage should be confined to indications prescribed by a...

USA: A Consensus Statement was issued to focus research activities and give evidence-based medical recommendations for pregnant women who take Paracetamol (N-acetyl-p-aminophenol (APAP). The study's findings suggest that pregnant women should take APAP with caution and for the least amount of time feasible. Long-term or high-dose usage should be confined to indications prescribed by a doctor. Pregnant women often use APAP since regulatory authorities, such as the FDA and EMA, have long deemed it safe to use during pregnancy when taken as recommended.

Ann Z. Bauer and colleagues review the epidemiological research and animal studies that have studied neurological, urogenital, and reproductive effects linked with maternal and perinatal use of APAP in this article. The findings of this study were published in Nature Reviews Endocrinology on 23rd September 2021.

The work of a worldwide panel of specialists, including physicians, epidemiologists, and fundamental scientists, resulted in this Consensus Statement. The 13 writers produced the declaration independently of individual groups and universities. The reference lists of the publications that were discovered were then searched for more relevant articles. Only studies that looked at APAP as an independent exposure were included. An executive writing group created the initial text after debate and deliberation among the writers, which was sent to all authors for critical evaluation. In addition to the 13 writers, 78 signees endorsed the final declaration, which takes into account diverse foreign viewpoints, prescription patterns, and clinical concerns.

APAP has been shown to penetrate the placenta and the blood-brain barrier49,50. Changes in APAP metabolism occur during pregnancy, which may render pregnant women and their foetuses more sensitive to harmful consequences. Increasing clinical data shows that APAP's activity in suppressing prostaglandin signalling in the third trimester can result in ductus arteriosus constriction, which can result in fetal loss or life-threatening cardiac failure in the new-born. Taken together, APAP possesses several of the important criteria for identifying an endocrine-disrupting chemical's danger.

Five of these studies' findings imply that prenatal APAP exposure is linked to male urogenital and reproductive system abnormalities, including an increased chance of male undescended testicles (cryptorchidism) and a shorter anogenital distance (AGD). Furthermore, exposure to APAP for more than two weeks raised the chance of cryptorchidism. Although not directly connected to evidence of APAP's effects in utero, studies have found that adult males who took APAP had a longer time to conception, lower testosterone levels, and sperm abnormalities such as DNA fragmentation.

A large number of studies have been conducted, with 26 of these studies identifying positive associations between APAP exposure during pregnancy and a variety of clinically assessed and parent-reported neurodevelopmental outcomes, primarily attention deficit hyperactivity disorder (ADHD) and related behavioral abnormalities, but also autism spectrum disorder (ASD), language delays, decreased IQ, cerebrum malformations, and cerebrovascular disease.

In conclusion, considering the high frequency of APAP usage among pregnant women, and its documented effects on the system, the public health consequences of reducing use might be significant.

Reference:

Bauer, A. Z., Swan, S. H., Kriebel, D., Liew, Z., Taylor, H. S., Bornehag, C.-G., Andrade, A. M., Olsen, J., Jensen, R. H., Mitchell, R. T., Skakkebaek, N. E., Jégou, B., & Kristensen, D. M. (2021). Paracetamol use during pregnancy — a call for precautionary action. Nature Reviews Endocrinology. https://doi.org/10.1038/s41574-021-00553-7

paracetamolpregnancyNature Reviews Endocrinology
Source : Nature Reviews Endocrinology
MD Editorial Team
MD Editorial Team

    Medical Dialogues consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers. Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.

    Show Full Article
    Next Story
    Similar Posts
    NO DATA FOUND

    Editorial

    Journal Club Today

    Health News Today

    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    X
    X