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  • Fenugreek seed extract...

Fenugreek seed extract shown to be beneficial for women with PCOS: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-10-21T12:30:04+05:30  |  Updated On 21 Oct 2022 4:04 PM IST
Fenugreek seed extract shown to be beneficial for women with PCOS: Study
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USA: A proprietary fenugreek seed extract, Furocyst, was shown as a safe, natural phytochemical-based formulation in a recent study to reduce the symptoms of polycystic ovary syndrome (PCOS). No significant adverse events were seen. The findings appear in the Journal of the American Nutrition Association.

The role of fenugreek in the control and prevention of diabetes is well established. The seeds improve blood sugar control and insulin resistance, which is critical for controlling PCOS. It may also help to aid weight loss, lower cholesterol, and promote healthy heart function.

Polycystic ovary syndrome is characterized by hyperandrogenemia, menstrual irregularity, elevated androgen levels, and hirsutism. It could result in infertility or miscarriage and is a challenging problem for physicians. The researchers demonstrated the efficacy of Furocyst, a patented, standardized Trigonella foenum-graecum extract, in ameliorating polycystic ovary syndrome symptoms for 90 consecutive days among fifty premenopausal women in a one-arm, non-randomized preliminary investigation.

In a recent study, a double-blind, two-arm, single-center, randomized, comparative analysis, Debasis Bagchi, Texas Southern University, Houston, Texas, USA, and colleagues aimed to assess the effectiveness of Furocyst (2 capsules of 500 mg/day) in 208 premenopausal women with PCOS diagnosis.

For the study, the researchers obtained the approval of the ethical committee. The investigation was completed by a total of 208 participants (placebo

= 95; Furocyst = 113; age:18-45 years, BMI < 42 kg/m2). The efficacy of the Furocyst and placebo were compared and assessed on the ovarian volume, the number of cysts, LH: FSH ratio, hirsutism, prolactin, and free testosterone. The researchers also assessed key clinical parameters, including HOMA Index, fasting blood glucose levels, LDL, cholesterol, and triglyceride levels, as well as total blood chemistry.

The study demonstrated the following findings:

  • Furocyst supplementation significantly reduced ovarian volume, the number of cysts, and hirsutism levels and normalized the menstrual cycle in Furocyst-treated subjects compared to the placebo group.
  • Furocyst remarkably reduced luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels, thyroid stimulating hormone (TSH) levels, and reduced the levels of prolactin and SHBG.
  • Furocyst significantly reduced the fasting blood glucose levels, HOMA Index, cholesterol, LDL, and triglyceride levels compared to the placebo group. In contrast, the free testosterone levels were significantly decreased in the Furocyst group.

"The study showed the efficacy of Furocyst as a safe, natural phytochemical-based formulation for alleviating PCOS symptoms," the researchers wrote in their conclusion. "No significant adverse events were seen."

Reference:

Singh, Amarjeet, et al. "Efficacy of a Proprietary Fenugreek Seed Extract (Trigonella Foenum-graecum, Furocyst®) in Women With Polycystic Ovary Syndrome (PCOS): a Randomized, Double-Blind, Placebo-Controlled Study." Journal of the American Nutrition Association, 2022, pp. 1-9.

Journal of the American Nutrition AssociationFurocystPCOSFenugreek SeedsPolycystic Ovary Syndrome
Source : Journal of the American Nutrition Association
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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