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Gabapentin effective in Hyperemesis Gravidarum in early pregnancy, finds study
According to a recent study, gabapentin therapy has proved to be more effective than standard-of-care therapy for Hyperemesis Gravidarum (HG) symptoms in pregnancy.The researchers went on to emphasize on favorable safety of gabapentin use during early pregnancy, proving that gabapentin therapy may be able to provide Hyperemesis Gravidarum patients and their infants with improved...
According to a recent study, gabapentin therapy has proved to be more effective than standard-of-care therapy for Hyperemesis Gravidarum (HG) symptoms in pregnancy.The researchers went on to emphasize on favorable safety of gabapentin use during early pregnancy, proving that gabapentin therapy may be able to provide Hyperemesis Gravidarum patients and their infants with improved long-term prognoses.
The findings have been published in Obstetrics & Gynecology.
Hyperemesis gravidarum (HG) is a disabling disease of early pregnancy for which there are no effective outpatient therapies. Because of the severe and persistent physical and psychological distress caused by HG, about 15% of HG pregnancies are terminated in the first trimester.
It is extreme, persistent nausea and vomiting during pregnancy. It can lead to dehydration, weight loss, and electrolyte imbalances. Morning sickness is mild nausea and vomiting that occurs in early pregnancy
The present study undertaken by Guttuso et al , aimed at assessing the effects of Gabapentin's on Hyperemesis Gravidarum.
The study was designed as A randomized, double-blind, multi-center trial conducted among patients with medically-refractory HG. Subjects were randomized (1:1) to either oral gabapentin (1,800–2,400 mg a day) or an active comparator arm of either oral ondansetron (24–32 mg a day) or oral metoclopramide (45–60 mg a day) for 7 days. Change in Motherisk-PUQE scores from baseline to Days 5–7 served as the primary endpoint.
On data analysis, the following facts emerged.
- Thirty-one patients were enrolled from 10/2014–5/2019. Among the 21 subjects providing any primary outcome data (12 assigned to gabapentin, 9 to the active comparator arm), 18 were enrolled as outpatients and all 21 were outpatients on Days 5–7.
- Intention-to-treat analysis showed the gabapentin treatment arm to have greater reductions in Motherisk-PUQE scores (P5.005) and increases in oral nutrition (P5.007) from baseline as well as higher global satisfaction (P5.02), relief (P,.05) and desire to continue therapy (P5.04) compared to the active comparator arm.
- Adverse events and number of subject withdrawals were equivalent between the group
For full article follow the link: doi:10.1097/01.aog.0000664012.26321.e3
Primary source: Obstetrics & Gynecology
Dr Satabdi Saha (BDS, MDS) is a practicing pediatric dentist with a keen interest in new medical researches and updates. She has completed her BDS from North Bengal Dental College ,Darjeeling. Then she went on to secure an ALL INDIA NEET PG rank and completed her MDS from the first dental college in the country – Dr R. Ahmed Dental College and Hospital. She is currently attached to The Marwari Relief Society Hospital as a consultant along with private practice of 2 years. She has published scientific papers in national and international journals. Her strong passion of sharing knowledge with the medical fraternity has motivated her to be a part of Medical Dialogues.