Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • MD Brand Connect
  • Vaccine Hub
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
  • Fact Check
  • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Fact Check
      • Bone Health Fact Check
      • Brain Health Fact Check
      • Cancer Related Fact Check
      • Child Care Fact Check
      • Dental and oral health fact check
      • Diabetes and metabolic health fact check
      • Diet and Nutrition Fact Check
      • Eye and ENT Care Fact Check
      • Fitness fact check
      • Gut health fact check
      • Heart health fact check
      • Kidney health fact check
      • Medical education fact check
      • Men's health fact check
      • Respiratory fact check
      • Skin and hair care fact check
      • Vaccine and Immunization fact check
      • Women's health fact check
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Abroad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
      • Medical Dialogues Show
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Fact Check
    • Bone Health Fact Check
    • Brain Health Fact Check
    • Cancer Related Fact Check
    • Child Care Fact Check
    • Dental and oral health fact check
    • Diabetes and metabolic health fact check
    • Diet and Nutrition Fact Check
    • Eye and ENT Care Fact Check
    • Fitness fact check
    • Gut health fact check
    • Heart health fact check
    • Kidney health fact check
    • Medical education fact check
    • Men's health fact check
    • Respiratory fact check
    • Skin and hair care fact check
    • Vaccine and Immunization fact check
    • Women's health fact check
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Abroad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Obstetrics and Gynaecology
  • Obstetrics and Gynaecology News
  • Gut bacteria and amino...

Gut bacteria and amino acid imbalance linked to higher miscarriage risk in women with PCOS: Study

Dr. Kamal Kant KohliWritten by Dr. Kamal Kant Kohli Published On 2025-07-08T21:00:15+05:30  |  Updated On 8 July 2025 9:00 PM IST
Gut bacteria and amino acid imbalance linked to higher miscarriage risk in women with PCOS: Study
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • Email

A new study presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) reveals that women with polycystic ovary syndrome (PCOS) have distinct gut microbiota and metabolic signatures linked to premature endometrial ageing and a higher risk of adverse pregnancy outcomes.

The research highlights a sharp reduction in the beneficial gut bacterium Parabacteroides merdae (P. merdae), alongside elevated levels of branched-chain amino acids (BCAAs), particularly isoleucine-an essential amino acid involved in protein production and energy metabolism. Together, these changes may act as potential drivers of poor endometrial function and reproductive complications in women with PCOS.

Affecting up to one in five women of reproductive age globally, PCOS is a major cause of infertility. Although fertility treatments often succeed in helping women with PCOS conceive, they remain at higher risk of complications such as miscarriage, preterm birth, and gestational diabetes. Until now, the mechanisms behind this elevated risk have remained unclear.

“In clinical practice, we noticed that even younger women with PCOS who achieved pregnancy still faced unexpectedly high rates of miscarriage and other complications”, said Dr. Aixia Liu, the lead author of the study. “Many of these women also had metabolic imbalances and digestive issues, which led us to explore the possible interplay between the gut microbiota, circulating metabolites, and the uterus.”

The prospective study followed 220 women under the age of 35 across 44 cities in China, including 110 PCOS patients and 110 matched controls. Researchers used a combination of gut microbiome sequencing and metabolomics to profile differences between the groups and conducted laboratory studies on endometrial stromal cells (ESCs) to assess ageing and decidualisation, a process critical for embryo implantation.

Results showed a significant reduction in microbial diversity among PCOS patients, particularly a decrease in P. merdae, a species linked to metabolic health. Serum metabolomics revealed elevated levels of BCAAs, especially isoleucine, and reduced levels of short-chain fatty acids in the PCOS group.

Despite similar pregnancy rates, women with PCOS were nearly twice as likely (1.95 times) to experience at least one adverse pregnancy outcome, including miscarriage, preterm birth, macrosomia, low birth weight, gestational diabetes, hypertensive disorders, and perinatal death.

Further investigation revealed that isoleucine levels were also elevated in endometrial tissue. When researchers exposed ESCs to isoleucine in the lab, they observed increased markers of cellular senescence and reduced capacity for decidualisation. “These findings indicate ageing-like changes in the uterus, occurring much earlier than expected”, said Dr. Liu. “Our data suggest that high isoleucine levels and the loss of P. merdae may impair endometrial health, even in women under 35.”

The researchers propose that P. merdae and BCAAs could serve as biomarkers for identifying high-risk PCOS patients and may guide personalised treatment approaches in the future. “The next step is to explore whether dietary interventions, probiotics, or BCAA-restricted diets can reverse these effects and improve pregnancy outcomes”, concluded Dr. Liu.

Professor Dr. Anis Feki, Chair-Elect of ESHRE, added, “The study provides compelling evidence that metabolic and microbial imbalances in PCOS are not only systemic but may directly impair endometrial receptivity, even in younger women. These findings mark a critical step toward personalised reproductive care in PCOS.”

Reference:

Gut bacteria and amino acid imbalance linked to higher miscarriage risk in women with PCOS, European Society of Human Reproduction and Embryology, Meeting: ESHRE 41st Annual Meeting.

European Society of Human Reproduction and EmbryologyGut bacteriamiscarriagePCOSpolycystic ovary syndromepregnancy
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

Show Full Article
Next Story

Editorial

Featured image representing orthopaedic care

Modern Orthopaedic Care: How Is Technology Improving Movement and Recovery? - Dr Abhijit Lonari

Aspirin in Primary Prevention of Stroke-Review of Evidence Through the Needs of Indian Clinical Settings

Aspirin in Primary Prevention of Stroke-Review of Evidence Through the Needs of Indian Clinical...

Dapagliflozin Shines in Post-TAVI Patients:DAPA-TAVI Trial Findings

Dapagliflozin Shines in Post-TAVI Patients:DAPA-TAVI Trial Findings

Identifying Candidates for Aspirin in Primary Prevention: Men Aged 40-50 with Hypertension, Dyslipidemia, and Familial ASCVD Risk

Identifying Candidates for Aspirin in Primary Prevention: Men Aged 40-50 with Hypertension,...

Featured image representing thinking

Is Pharma Marketing Going Through "Thinking Recession"?

View All

Journal Club Today

Is Your Brain Aging Too Fast? New Study Can Tell from One Brain Scan

Is Your Brain Aging Too Fast? New Study Can Tell from One Brain Scan

View All

Health News Today

Health Bulletin 8/July/ 2025

Health Bulletin 8/July/ 2025

View All
© 2022 All Rights Reserved.
Powered By: Hocalwire
X
We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok