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  • Hop based Dietary...

Hop based Dietary supplements used during menopause don't increase drug interactions

Written By : Dr. Kamal Kant Kohli Published On 2020-05-19T22:09:16+05:30  |  Updated On 19 May 2020 10:09 PM IST
Hop based Dietary supplements used during menopause dont increase drug interactionsCAPTION Dietary supplements made from hops are used to combat the night sweats and hot flashes commonly reported during menopause. CREDIT Photo courtesy Oregon State University
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Hormone replacement therapy remains the standard of care for menopausal patients but it is not suitable for all women. Some studies have suggested hormone replacement therapy puts women at an increased risk for breast cancer and cardiovascular disease, sparking interest in alternative treatments.

Researchers at Oregon State University's Linus Pauling Institute and College of Pharmacy have found in a new study that hop-based dietary supplements used to ease the night sweats and hot flashes commonly reported during menopause aren't likely to cause drug interactions.

The findings of the study have been published in the Journal of Agricultural and Food Chemistry.

Hops are the flowers of the hop plant and are what give beer its bitter flavor. Supplements made from hops can be effective for alleviating menopausal symptoms because hops contain phytoestrogens. Phytoestrogens are plant-based compounds that mimic the action of female sex hormones, whose deficiency is at the root of symptoms often felt by women in menopause, which also include sleep disturbances, fatigue and vaginal dryness.

"There are reports from other lab studies that compounds from hops may inhibit or deactivate certain drug-metabolizing enzymes," said the study's lead investigator and corresponding author, Richard van Breemen, director and principal investigator of the Linus Pauling Institute. "There is additional concern because we know the compounds in hops have a long half-life in humans, possibly more than 20 hours after taking them."

The long half-life means hops supplements may still be found in the bloodstream when women take drugs they are prescribed. Because these botanical supplements are made from plants, many people don't think of the possibility of drug interactions when they take them.

To determine hops' effect on drug-metabolizing enzymes, the scientists gave 16 research subjects a cocktail of four drugs, each one primarily metabolized by a different enzyme in a family of enzymes known as cytochrome P450s. The drugs were caffeine; alprazolam, an anti-anxiety medicine sold under the trade name Xanax; dextromethorphan, an over-the-counter cough suppressant; and tolbutamide, a medicine used to treat type 2 diabetes.

"We did each drug trial twice. Once to see how these women metabolized the drugs normally," van Breemen explained. "Then we repeated the trial with hops after the participants took a hops extract twice daily for two weeks. Thankfully, no enzyme inhibition was detected."

Guidelines for clinical studies of drug interactions involving CYP enzymes have been set by the U.S. Food and Drug Administration, he noted.

"Under FDA guidelines, the hop dietary supplement caused no clinically relevant pharmacokinetic interactions" said co-author Luying Chen, a Ph.D. student in van Breemen's lab. "So we can say that hop dietary supplements are not expected to produce any harmful drug interactions, at least with respect to the enzymes probed during this investigation. More research is needed, but these findings are good news for women who take hops for relief of menopause symptoms."

For further reference log on to:

http://dx.doi.org/10.1021/acs.jafc.0c01077

Hop basedDietary supplementsmenopausal symptomsdrug interactions
Source : Oregon State University
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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