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  • Maternal autoimmune...

Maternal autoimmune diseases may increase risk of mental disorders among offsprings: JAMA

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-04-18T11:15:13+05:30  |  Updated On 18 April 2022 3:47 PM IST
Maternal autoimmune diseases may increase risk of mental disorders among offsprings: JAMA
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Prenatal exposure to maternal autoimmune diseases was associated with increased risks of overall and type-specific mental disorders in offspring, finds a new study.

Therefore offsprings of mothers with autoimmune diseases may benefit from long-term surveillance for mental disorders.

The study has been published in the JAMA Network Open.

Maternal immune activation during pregnancy is associated with increased risks of several mental disorders in offspring during childhood, but little is known about how maternal autoimmune diseases during pregnancy are associated with mental health in offspring during and after childhood.

A study was conducted to investigate the association between maternal autoimmune diseases before childbirth and the risk of mental disorders among offspring up to early adulthood.

This population-based nationwide cohort study used data from Danish national registers on singletons born in Denmark from 1978 to 2015 with up to 38 years of follow-up. Data analyses were conducted from March 1, 2020, through September 30, 2021. Maternal autoimmune disease is diagnosed before or during pregnancy according to the Danish National Patient Register. The main outcome was mental disorders, defined by hospital diagnoses, in offspring. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% CIs for mental disorders.

The results of the study are:

  • Of the 2 254 234 singleton infants included in the study, 2.26% were born to mothers with autoimmune diseases before childbirth.
  • Exposed participants had an increased risk of overall mental disorders compared with their unexposed counterparts.
  • Increased risks of overall mental disorders in offspring were seen in different age groups for type 1 diabetes and rheumatoid arthritis
  • Regarding specific mental disorders, increased risk after exposure to any maternal autoimmune disorder was observed for organic disorders, schizophrenia, obsessive-compulsive disorder (HR, 1.42; 95% CI, 1.24-1.63), mood disorders (HR, 1.12; 95% CI, 1.04-1.21), and a series of neurodevelopmental disorders (eg, childhood autism [HR, 1.21; 95% CI, 1.08-1.36] and attention-deficit/hyperactivity disorder

Thus, In this cohort study in Denmark, prenatal exposure to maternal autoimmune diseases was associated with increased risks of overall and type-specific mental disorders in offspring. Maternal type 1 diabetes and rheumatoid arthritis during pregnancy were associated with offspring's mental health up to early adulthood. Individuals prenatally exposed to autoimmune disease may benefit from long-term surveillance for mental disorders.

Reference:

Association of Maternal Autoimmune Diseases With Risk of Mental Disorders in Offspring in Denmark by Hua He, et al. published in the JAMA Netw Open

doi:10.1001/jamanetworkopen.2022.7503



Maternal autoimmune diseasemental disordersmental issueslong-term survillenceoffspringjama network open
Source : JAMA Network Open
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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