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  • Omega-3 fatty acids...

Omega-3 fatty acids intake during pregnancy may protect offsprings from breast cancer

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-06-30T09:00:26+05:30  |  Updated On 30 Jun 2021 10:30 AM IST
Omega-3 fatty acids intake during pregnancy may protect offsprings from breast cancer
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HUNTINGTON, W.Va. - Studies in the past have revealed that Diets rich in omega-3 fatty acids (FA) have been associated with lowered risks of developing certain types of cancers.

Researchers at Marshall University have found in a new study that a maternal diet rich in Omega-3 fatty acids protects from breast cancer development in offspring. The study has been published by Frontiers in Cell and Developmental Biology.

They noted a significant difference in mice from mothers that were fed a diet rich in canola oil, compared with mothers fed a diet rich in corn oil. A maternal Omega 3-rich diet affected genome-wide epigenetic landscape changes in offspring and potentially modulated gene expression patterns.

Alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are the three important omega-3 (ω-3) fatty acids (FA) (Lunn and Theobald, 2006; Glick and Fischer, 2013). ALA is an essential FA mainly found in plant oils such as canola oils, flaxseed, and soybean. Linoleic acid (LA) is an omega-6 (ω-6) FA and is also an essential FA that our body could not synthesize. The primary dietary sources of ω-6 FA are vegetable oils, including corn oil, sunflower oil, and soybean oil.

According to researchers at Marshall University, a maternal diet rich in Omega-3 fatty acids protects from breast cancer development in offspring. In a new study recently published by Frontiers in Cell and Developmental Biology,

Dr. Ata Abbas, a former postdoctoral research fellow in Marshall's Department of Biological Sciences, headed a research team under the leadership of Dr. Philippe Georgel in the College of Science. Research was done in the Cell Differentiation and Development Center at Marshall as part of a collaborative effort with the Joan C. Edwards School of Medicine's Department of Biochemistry and Microbiology, under the leadership of Dr. W. Elaine Hardman.

Researchers noticed a three-week delay in mortality in mice whose mothers were fed canola oil versus corn oil. The early delay in mortality was significantly different, but the ultimate overall survival rate was not. Eventually, all the mice developed tumors, but the ones fed canola oil had tumors that were slower-growing and smaller than the mice fed corn oil. Translated to human time scale, the duration of the protective effect linked to the maternal diet would be equivalent to several months (Sengupta et al., 2016).

This study is among a body of work done by Marshall University scientists and others looking at the link between Omega-3 fatty acids and reduced incidence of various types of cancer including, but not restricted to, Chronic Lymphocytic Leukemia and Diffuse Large B-Cell Lymphoma.

"The issue of parental diet and inter-generational transmission has become an important field of research; however, the mode of action often remains partially elusive," said Georgel, a professor in the Department of Biological Sciences at Marshall. "The MU research group focused on 'epigenetic' aspects of trans-generational transmission to explain the reported role of Omega-3 fatty acids. Epigenetics involves changes in gene expression which are not linked to changes in genetic sequences. These results have the potential to promote the design of simple changes in diet which would allow for reduced onset of various types of cancer, not only for the individuals using that diet but also for their offspring."

For further reference log on to:

http://dx.doi.org/10.3389/fcell.2021.682593




omega-3 fatty acidsmaternal dietsbreast cancerfrontiers in cell and developmental biologycanola oilchronic lymphocytic leukemiadiffuse large b-cell lymphoma
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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