Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • MD Brand Connect
  • Vaccine Hub
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
  • Fact Check
  • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Fact Check
      • Bone Health Fact Check
      • Brain Health Fact Check
      • Cancer Related Fact Check
      • Child Care Fact Check
      • Dental and oral health fact check
      • Diabetes and metabolic health fact check
      • Diet and Nutrition Fact Check
      • Eye and ENT Care Fact Check
      • Fitness fact check
      • Gut health fact check
      • Heart health fact check
      • Kidney health fact check
      • Medical education fact check
      • Men's health fact check
      • Respiratory fact check
      • Skin and hair care fact check
      • Vaccine and Immunization fact check
      • Women's health fact check
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Abroad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
      • Medical Dialogues Show
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Fact Check
    • Bone Health Fact Check
    • Brain Health Fact Check
    • Cancer Related Fact Check
    • Child Care Fact Check
    • Dental and oral health fact check
    • Diabetes and metabolic health fact check
    • Diet and Nutrition Fact Check
    • Eye and ENT Care Fact Check
    • Fitness fact check
    • Gut health fact check
    • Heart health fact check
    • Kidney health fact check
    • Medical education fact check
    • Men's health fact check
    • Respiratory fact check
    • Skin and hair care fact check
    • Vaccine and Immunization fact check
    • Women's health fact check
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Abroad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Obstetrics and Gynaecology
  • Obstetrics and Gynaecology News
  • Parental subfecundity...

Parental subfecundity or use of MAR doesn't negatively impact reproductive health of sons

Written By : Dr Nirali Kapoor |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-12-28T20:00:34+05:30  |  Updated On 28 Dec 2022 8:00 PM IST
Parental subfecundity or use of MAR doesnt negatively impact reproductive health of sons
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • Email

Infertility is an increasing global health problem,affecting approximately 15% of couples worldwide and male factor infertility isa major contributing factor. The decline in couple fecundity presumably iscaused by biological, social, and behavioral aspects. It has been suggestedthat family planning and use of contraception during the past century haveincreased subfecundity. The most fecund couples have fewer children, whereascouples with low fecundity produce more children than before due to fertilitytreatment. This hypothesis assumes that intergenerational transmission ofsubfecundity is substantial, which is poorly documented.

During the last decades, an increasing number of childrenhave been conceived by use of medically-assisted reproduction (MAR).Medically-assisted reproduction consists of a wide range of treatment optionsdepending on the underlying cause of infertility; from ovulation induction andintrauterine insemination (IUI) used in couples without male factorinfertility, to the more invasive and advanced techniques, such as in vitrofertilization (IVF) or intracytoplasmic sperm injection (ICSI). It is wellknown that poor semen quality is a major contributing cause of coupleinfertility, and for years, couples where the male has severely poor semenquality needed donor sperm to achieve a pregnancy by IVF.

Male factor infertility remains a major global healthproblem and natural concerns have been raised on whether poor semen quality isthe result of intergenerational transmission to the next male generations.Further, with the increasing use of MAR, in particular IVF and ICSI, there is aneed to investigate if any paternally inherited or technically associatedadverse effects may exist on reproductive health.

A cohort study carried out by Linn H. Arendt and team wasbased on total of 1,058 men in the Fetal Programming of Semen quality cohortfrom the Fetal Programming of Semen quality (FEPOS) cohort, a subcohort nestedwithin the Danish National Birth Cohort (DNBC).

From 2017–2019, men were recruited and provided semen andblood samples. Information on parental time to pregnancy and use ofmedically-assisted reproduction (including type of treatment) as well asdemographic, health, and lifestyle factors were available. Semencharacteristics (semen volume, sperm concentration, total sperm count, spermmotility, and morphology), testicular volume, and reproductive hormone levels(follicle stimulating hormone, luteinizing hormone, testosterone, estradiol,sex hormone-binding globulin, and free androgen index) were noted.

Overall, semen quality and levels of reproductive hormoneswere not lower among sons of subfecund parents reporting a time to pregnancy>6 months or use of intrauterine insemination. Sons conceived after in vitrofertilization or intracytoplasmic sperm injection, had a higher semen concentration(29%) and a higher percentage of sperm with normal morphology (20%), but with95% CI overlapping the null. Moreover, these sons had slightly higher estradiollevels (30%). The absolute differences seen were small, and the clinicalsignificance of these differences are unknown.

In this nationwide population-based cohort study, authorsfound no major difference in semen quality or reproductive hormones in sonsconceived by subfertile couples or with the use of MAR. Thus, these data do notsupport the hypothesis that parental subfecundity was inherited, thus,affecting the semen quality of male offspring or that reproductive health insons was affected by parental MAR treatment.

In conclusion, authors found no evidence to support thehypothesis that parental subfecundity or use of MAR negatively affectsreproductive health in male offspring measured by semen quality or testicularvolume. However, they found a slightly altered hormonal profile of menconceived following IVF or ICSI. These results are reassuring for the manycouples worldwide struggling with subfecundity, but contradict previousfindings. The findings of this study thus need replication in futureindependent studies.

Source: Linn H.Arendt, Anne Gaml-Sorensen, Andreas Ernst; Fertilityand Sterility

https://doi.org/10.1016/j.fertnstert.2022.06.035

fertilityinfertilityreproductive hormonessemen quality
Source : Fertility and Sterility
Dr Nirali Kapoor
Dr Nirali Kapoor

    MBBS, MD Obstetrics and Gynecology

    Dr Nirali Kapoor has completed her MBBS from GMC Jamnagar and MD Obstetrics and Gynecology from AIIMS Rishikesh. She underwent training in trauma/emergency medicine non academic residency in AIIMS Delhi for an year after her MBBS. Post her MD, she has joined in a Multispeciality hospital in Amritsar. She is actively involved in cases concerning fetal medicine, infertility and minimal invasive procedures as well as research activities involved around the fields of interest.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

    Show Full Article
    Next Story

    Editorial

    ABYSS Trial Finds Elevated BP, HR & Deleterious CV Outcomes After Beta blocker Withdrawal Post-MI: EuroPCR 2025 Update

    ABYSS Trial Finds Elevated BP, HR & Deleterious CV Outcomes After Beta blocker Withdrawal Post-MI:...

    Aspirin Use in Male Smokers Aged 40-45 Years with Hypertension: Identifying the Ideal Candidates

    Aspirin Use in Male Smokers Aged 40-45 Years with Hypertension: Identifying the Ideal Candidates

    National Consensus 2025 on Role of Bisoprolol Across CV Continuum in Women: Top 10 Takeaways

    National Consensus 2025 on Role of Bisoprolol Across CV Continuum in Women: Top 10 Takeaways

    Relevance of Pioglitazone in Indian T2DM Care Continuum

    Relevance of Pioglitazone in Indian T2DM Care Continuum

    Azmarda Outperforms Generic Sacubitril/Valsartan in HFrEF Management, says new study

    Azmarda Outperforms Generic Sacubitril/Valsartan in HFrEF Management, says new study

    View All

    Journal Club Today

    AI vs. Clinicians: Study Explores the Future of Diagnosing in Healthcare

    AI vs. Clinicians: Study Explores the Future of Diagnosing in Healthcare

    View All

    Health News Today

    Health Bulletin 05/June/2025

    Health Bulletin 05/June/2025

    View All
    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    X
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok