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  • Paxlovid effective...

Paxlovid effective treatment in symptomatic pregnant women with SARS-CoV-2 Omicron variant infection

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-11-15T15:30:39+05:30  |  Updated On 15 Nov 2023 3:31 PM IST
Paxlovid effective treatment in symptomatic pregnant women with SARS-CoV-2 Omicron variant infection
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Nirmatrelvir/ritonavir is an effective treatment in symptomatic pregnant women with SARS-CoV-2 Omicron variant infection suggests a new study published in the Nature Medicine.

A study was done to date there is a lack of randomized trial data examining the use of the antiviral nirmatrelvir/ritonavir in SARS-CoV-2-infected pregnant persons. This target trial emulation study aims to address this gap by evaluating the use of nirmatrelvir/ritonavir in non-hospitalized pregnant women with symptomatic SARS-CoV-2 Omicron variant infection. Among patients diagnosed between 16th March 2022 and 5th February 2023, exposure was defined as outpatient nirmatrelvir/ritonavir treatment within five days of symptom onset or COVID-19 diagnosis.

Primary outcomes were maternal morbidity and mortality index (MMMI), all-cause maternal death, and COVID-19-related hospitalization, while secondary outcomes were individual components of MMMI, preterm birth, stillbirth, neonatal death, and caesarean section. One-to-ten propensity-score matching was conducted between nirmatrelvir/ritonavir users and non-users; followed by cloning, censoring, and weighting. Overall, 211 pregnant women on nirmatrelvir/ritonavir and 1,998 non-users were included. Nirmatrelvir/ritonavir treatment was associated with reduced 28-day MMMI risk (absolute risk reduction [ARR] = 1.47%, 95%CI = 0.21%-2.34%); but not 28-day COVID-19-related hospitalization (ARR = -0.09%, 95%CI = -1.08%-0.71%).

Nirmatrelvir/ritonavir treatment was also associated with reduced risks of caesarean section (ARR = 1.58%, 95%CI = 0.85%-2.39%); and preterm birth (ARR = 2.70%, 95%CI = 0.98%-5.31%). No events of maternal or neonatal death or stillbirth were recorded. The findings suggest nirmatrelvir/ritonavir is an effective treatment in symptomatic pregnant women with SARS-CoV-2 Omicron variant infection.


Reference:

Wong, C.K.H., Lau, K.T.K., Chung, M.S.H. et al. Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 Omicron infection: a target trial emulation. Nat Med (2023). https://doi.org/10.1038/s41591-023-02674-0

Keywords:

Wong, C.K.H., Lau, K.T.K., Chung,. Nirmatrelvir/ritonavir, use, pregnant, women, SARS-CoV-2, Omicron, infection, target, trial, emulation, Nat Med



Nirmatrelvir/ritonavirusepregnantwomenSARS-CoV-2OmicroninfectiontargettrialemulationNat Med
Source : Nature Medicine
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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