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Pregnancies where one parent has OI result in live births to term with very few pregnancy related complications: Study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-08-08T20:45:42+05:30  |  Updated On 9 Aug 2024 4:00 PM IST
Pregnancies where one parent has OI result in live births to term with very few pregnancy related complications: Study
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Researchers have found that pregnancies in patients with Osteogenesis Imperfecta (OI) generally result in healthy, full-term births with few complications, according to a new nationwide, register-based cohort study conducted in Denmark. This study was published in the journal Bone conducted by Emilie K. and colleagues.

Osteogenesis Imperfecta (OI) is a hereditary bone disease characterized by brittle bones and an increased tendency to develop fractures. Due to such complications, doubts have been made regarding the safety of pregnancy in OI subjects. In this way, this was the first study designed to investigate the risk of complications related to pregnancy, delivery, and offspring when one of the parents has OI.

This study was based on Danish health register-based data from 1997 to 2018. The population had all pregnancies where either the mother or father suffered from OI, compared with a reference population comprising all other pregnancies in the general population. The data was analyzed by descriptive epidemiology.

The key findings of the study were:

• OI-associated pregnancies in 433 cases, where 134 mothers and 73 fathers had OI.

• And the number of incidences of complications related to pregnancy and childbirth, like pre-eclampsia, eclampsia, and perinatal hemorrhage, were about the same in the OI cohorts as in the normal population.

• More children were delivered by cesarean section in the OI cohort (31%) compared to the reference population (19%).

• The study found no significant increase in complications among offspring, including low birth weight, low Apgar scores, the need for CPAP or NICU, congenital malformations, incidence of OI, birth-related fractures, or hospital contacts during the first year of life.

The results show that pregnancies in OI patients are not more at risk than the population. This is very important, taking into consideration the fear of complications that may deter one with OI from ever trying to fall pregnant. The increased rate of cesarean section within the OI cohort of this study is significant, but this was not reflected in increased rates of bad outcomes for mother or baby.

In general, pregnancies with a partner or parent affected by osteogenesis imperfecta result in live births at term with very few complications. This study provides reassuring evidence that, despite the inherent challenges of OI, pregnancy can be safely managed in this population.

Reference:

Lykking, E. K., Damkier, P., Kammerlander, H., Broe, A., & Folkestad, L. (2024). Pregnancy complications and birth outcome in patients with osteogenesis imperfecta – A population-based register study. Bone, 117202, 117202. https://doi.org/10.1016/j.bone.2024.117202

BoneOsteogenesis imperfectapregnancy complicationshereditary diseasebone fragilityDanish health registercaesarean section
Source : Bone
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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