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Pregnant Women with Psoriasis at Increased Risk of Ectopic Pregnancy: Study

Dr. Shravani DaliWritten by Dr. Shravani Dali Published On 2022-05-13T19:00:56+05:30  |  Updated On 13 May 2022 1:31 PM GMT
Pregnant Women with Psoriasis at Increased Risk of Ectopic Pregnancy: Study
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Pregnant women with psoriasis at increased risk of ectopic pregnancy, according to a recent study published in the JAAD International. The chronic systemic inflammation associated with psoriasis supposedly creates an undesirable milieu for a pregnancy, resulting in an increased risk of adverse pregnancy outcomes (APOs). A study was conducted to investigate the association between...

Pregnant women with psoriasis at increased risk of ectopic pregnancy, according to a recent study published in the JAAD International.

The chronic systemic inflammation associated with psoriasis supposedly creates an undesirable milieu for a pregnancy, resulting in an increased risk of adverse pregnancy outcomes (APOs). A study was conducted to investigate the association between psoriasis and APOs and how the association differs according to psoriasis severity (mild and moderate-to-severe). This nationwide register-based case-control study collected data from 1973 to 2017. Cases were adverse pregnancy outcomes (spontaneous abortion, ectopic pregnancy [EP], intrauterine fetal death, and stillbirth). Singleton live births were controlled. Adjusted logistic regression models were used for statistical analyses.

Results of the study:

In total, 42,041 (8.56%) APOs and 449,233 (91.44%) controls were included. Ectopic pregnancy was the only adverse pregnancy outcome that was found to be statistically associated with psoriasis (odds ratio, 1.34; 95% CI, 1.06-1.68). Odds ratio for ectopic pregnancy was the highest for women with moderate-to-severe psoriasis (odds ratio, 2.77; 95% CI, 1.13-6.76). The absolute risk of Ectopic pregnancy was 2.48% higher for women with moderate-to-severe psoriasis compared with women without psoriasis (3.98% vs 1.50%).

Limitations of the study:

No access to clinical data confirming psoriasis severity.

Thus, the present study found a significant association between EP and psoriasis (absolute risk of 3.98%). As EP is the leading cause of maternal morbidity and mortality in the first trimester of pregnancy, our findings call for particular care for women of reproductive age with psoriasis.

Reference:

Psoriasis and adverse pregnancy outcomes: A nationwide case-control study in 491,274 women in Denmark by Cæcilie Bachdal Johansen, et al. published in the JAAD International.

https://www.jaadinternational.org/article/S2666-3287%2822%2900038-4/fulltext#%20

Keywords:

Psoriasis, adverse, pregnancy, outcomes, nationwide, case-control, study, women, Denmark, Cæcilie Bachdal Johansen, Alexander Egeberg, Espen Jimenez-Solem, Lone Skov, Simon Francis Thomsen, JAAD International, adverse pregnancy outcomes, ectopic pregnancy, fetal death, pregnancy outcome, psoriasis, psoriasis severity, spontaneous abortion, stillbirth, women


JAAD InternationalPregnant WomenPsoriasisriskEctopic Pregnancy
Source : JAAD International
Dr. Shravani Dali
Dr. Shravani Dali

    BDS

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

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