Maternal and neonatal morbidity and mortality rates not different among patients with ITP despite different platelet counts: Study

This study aimed to compare the maternal and neonatal outcomes in pregnant women diagnosed with idiopathic thrombocytopenic purpura (ITP) in our clinic between different platelet groups. This study was designed retrospectively. A total of 62 pregnant women with idiopathic thrombocytopenic purpura were included in the study. Demographic and clinical data for all cases were evaluated. Perinatal outcomes were evaluated according to platelet counts.Results: The median age of the patients participating in the study was 27, and their ages ranged from 21 to 44. ITP was diagnosed before pregnancy in 32.3 % (n=20) of the patients and during pregnancy in 67.7 % (n=42).

The average platelet counts of the patients during the first trimester and birth were 104.8/μL (15-168) and 84/μL (16-235), respectively. The average platelet count of newborns is 242/μL. The most common (74.2 %) ITP treatment method is the combination of steroids and IVIG. The platelet count of 80.6 % of newborns is above 151/μL. There was no statistical difference between the results of both mothers and fetuses when the groups were categorized according to maternal platelet levels. In this study, no difference was observed in maternal and neonatal morbidity and mortality rates, despite the different platelet counts of patients with idiopathic thrombocytopenic purpura. The cooperation of the hematology, gynecology, obstetrics, and neonatology departments is responsible for this.

Reference:

Ezveci, Huriye, et al. "Perinatal Outcomes in Pregnant Women With ITP: a Single Tertiary Center Experience." Journal of Perinatal Medicine, 2024.