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Women with Endometriosis and uterine fibroids likely to have Premature death, suggests study

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-12-25T20:15:06+05:30  |  Updated On 25 Dec 2024 8:15 PM IST
relugolix in endometriosis
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A new study published in the British Medical Journal showed that women who have a history of uterine fibroids and endometriosis may be more likely to die young after they have finished having children. With clinically significant prevalences of 10% and 15% to 30%, respectively, endometriosis and uterine fibroids are prevalent conditions among women in their reproductive years.

Growth of endometrial-like tissue outside the uterus is a hallmark of endometriosis. Uterine fibroids, on the other hand, are smooth muscle cell-based, non-cancerous tumors that usually develop inside or near the myometrium. But uterine fibroids and endometriosis have similar genetic roots, and they grow through a combination of proinflammatory, immunological, and endocrine mechanisms. As a result, Yi-Xin Wang looked at how endometriosis and uterine fibroids affected the long-term risk of premature death in women from the Nurses' Health Study II (NHSII), which has been conducted every two years for 30 years in the United States.

In 1989, 110,091 women between the ages of 25 and 42 who had never had a hysterectomy previously were diagnosed with cancer, cardiovascular disease, or endometriosis or fibroids were included. The key performance indicators Hazard ratios (calculated using Cox proportional hazards models) for overall and cause-specific premature death based on uterine fibroids confirmed by ultrasound or hysterectomy or endometriosis verified by laparoscopy and reported in biennial questionnaires.

Over the course of 2994,354 person years of follow-up, 4356 premature deaths were documented, including 90 from respiratory illnesses, 304 from cardiovascular disorders, and 1459 from cancer. Women with and without laparoscopically diagnosed endometriosis had crude incidences of all-cause premature death of 2.01 and 1.40 per 1000 person years, respectively.

Laparoscopically verified endometriosis was linked to a hazard ratio of 1.19 for premature mortality in age-adjusted models and these models were reinforced after controlling for behavioral variables and other possible confounders. In cause-specific mortality studies, uterine fibroids verified by ultrasound or hysterectomy were linked to a higher chance of dying from a malignant tumor of gynecological organs, but not to all cause premature death.

Women who reported both endometriosis and uterine fibroids had a higher risk of premature mortality from all causes. Overall, women who had a history of endometriosis and uterine fibroids were more likely to die young and die from gynecological malignancies.

Source:

Wang, Y.-X., Farland, L. V., Gaskins, A. J., Wang, S., Terry, K. L., Rexrode, K. M., Rich-Edwards, J. W., Tamimi, R., Chavarro, J. E., & Missmer, S. A. (2024). Endometriosis and uterine fibroids and risk of premature mortality: prospective cohort study. In BMJ (p. e078797). BMJ. https://doi.org/10.1136/bmj-2023-078797

British Medical Journalpremature deathendometriosisuterine fibroids
Source : British Medical Journal
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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