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Case of advanced mycosis fungoides reported in NEJM

Dr. Kamal Kant KohliWritten by Dr. Kamal Kant Kohli Published On 2020-04-07T18:04:41+05:30  |  Updated On 7 April 2020 12:34 PM GMT
Case of advanced mycosis fungoides reported in NEJM
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Dr Hasina Maredia and Sima Rozati at Johns Hopkins University School of Medicine, Baltimore have reported a rare case of advanced mycosis fungoides. The case has been published in the New England Journal of Medicine.Cutaneous T-cell lymphoma (CTCL) comprises a clinically/pathologically heterogeneous group of uncommon non-Hodgkin's lymphomas that manifest primarily in the skin....

Dr Hasina Maredia and Sima Rozati at Johns Hopkins University School of Medicine, Baltimore have reported a rare case of advanced mycosis fungoides. The case has been published in the New England Journal of Medicine.

Cutaneous T-cell lymphoma (CTCL) comprises a clinically/pathologically heterogeneous group of uncommon non-Hodgkin's lymphomas that manifest primarily in the skin. Mycosis fungoides (MF) is the most common CTCL subtype that accounts for around 60% of CTCL (1).

It is a rare form of T-cell lymphoma of the skin (cutaneous); the disease is typically slowly progressive and chronic. In individuals with mycosis fungoides, the skin becomes infiltrated with plaques and nodules that are composed of lymphocytes. In advanced cases, ulcerated tumors and infiltration of lymph nodes by diseased cells may occur. The disorder may spread to other parts of the body including the gastrointestinal system, liver, spleen, or brain.

Cutaneous T-cell lymphoma (CTCL) comprises a clinically/pathologically heterogeneous group of uncommon non-Hodgkin's lymphomas that manifest primarily in the skin. Mycosis fungoides (MF) is the most common CTCL subtype that accounts for around 60% of CTCL.

It is a rare form of T-cell lymphoma of the skin (cutaneous); the disease is typically slowly progressive and chronic.

In individuals with mycosis fungoides, the skin becomes infiltrated with plaques and nodules that are composed of lymphocytes. In advanced cases, ulcerated tumors and infiltration of lymph nodes by diseased cells may occur. The disorder may spread to other parts of the body including the gastrointestinal system, liver, spleen, or brain.

According to history a 53-year-old man with a history of treated stage 1A mycosisk fungoides that had been diagnosed 7 years earlier presented with a 2-month history of new and rapidly progressing lesions on his face and body.

His examination of the head and neck showed multiple coalescing subcutaneous nodular lesions and deep furrowing of skin folds that resulted in the distortion of the patient's facial features.

Also present were numerous hyperpigmented erythematous nodules, as well as crusted hyperkeratotic tumors affecting approximately 85% of the patient's total body surface area. Flow cytometry of the peripheral blood identified a small population of atypical lymphocytes, and positron-emission tomography showed increased fluorodeoxyglucose uptake in the cervical, axillary, and pelvic lymph nodes, as well as in the spleen and liver. A skin biopsy confirmed the diagnosis of mycosis fungoides with CD30-expressing large-cell transformation.

The patient began a regimen of brentuximab, cyclophosphamide, doxorubicin, and prednisone, and notable improvement was seen after two cycles .

For further reference log on to:

DOI: 10.1056/NEJMicm1911156

Mycosis fungoidesSézary syndromeNew England Journal of Medicine
Source : New England Journal of Medicine
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Before Joining Medical Dialogues, he has served at important positions in the medical industry in India including as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils in India. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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