2 Years of Treatment, 7 Years of Benefits: Abemaciclib Delivers New Overall Survival Data in Breast Cancer Patients - Video
Overview
In this short video, Dr Nitesh Rohtagi, Principal Director, Department of Medical Oncology, Fortis Cancer Institute, Delhi and Gurugram, discusses key findings from ESMO 2025, highlighting that 2-year Abemaciclib therapy shows increasing benefit at seven years for patients with early breast cancer.1,2
With a 16.5% reduction in the risk of death, it is a clear confirmation that Abemaciclib in early breast cancer given for 2 years has an overall survival advantage. 1,2,3,4,5 It is also seen that deaths due to breast cancer are reduced from 11% to 8.3%. He also emphasized that there's a ~30% reduction in the number of patients living with metastatic disease than the control arm. It seems that this number will continue to become more apparent.1
Abemaciclib, only CDK4 inhibitor, demonstrated a sustained an Invasive disease-free survival (IDFS) benefit at 7 years with just 2 years of therapy. It also delivers a long lasting protection by reducing the risk of recurrence of incurable metastatic disease. 1,2
This is the longest follow-up ever reported with the CDK4/6 inhibitor in early breast cancer. Specifically, for the highest population which in India unfortunately is high, this two year’s treatment showing seven years’ benefit is meaningful and impactful. 1,3,5,6
Tolerability has always been a point of discussion, but Abemaciclib demonstrated a reversible and manageable safety profile, with 81.5% of patients in the monarchE trial remaining on treatment. Most adverse events were predictable, tolerable, and low grade. The most common adverse effect was diarrhea, with a median time to onset of approximately 8 days and an average duration of 5 to 6 days. Notably, 94.7% of patients in monarchE continued treatment despite experiencing diarrhea, highlighting that with appropriate counseling and close support, patients can successfully manage toxicity.6,7,8
When dose reductions are necessary to help patients manage side effects, Abemaciclib remains effective, and efficacy is preserved.6
Reference: 1 Johnston S, Martin M, O'Shaughnessy J, et al. Ann Oncol. 2025. DOI: 10.1016/j.annonc.2025.10.005 ESMO Presentation. 2025. 2. Ramiven India API Version Control No .: PA008SPIN05. 3. Hortobagyi GN, et al. Ann Oncol. 2025;36(2):149-57. 4. Ribociclib. Summary of Product Characteristics. April 2025. 5. Rastogi P, et al. J Clin Oncol. 2024;42(9):987-93. 5. Ramiven India API Version Control No .: PA008SPIN05. 6. Goetz MP, et al. NPJ Breast Cancer. 2024;10(1):34 (+Suppl. Appendix) 7. Johnston SRD, et al. Lancet Oncol. 2023;24(1):77-90. 8. Rugo HS, et al. Ann Oncol. 2022;33(6):616-27.
PP-AL-IN-1852 | 17/12/2025
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