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Antiemetic fosnetupitant safe in breast cancer patients receiving AC/EC: study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-04-02T15:00:49+05:30  |  Updated On 2 April 2022 3:00 PM IST
Antiemetic fosnetupitant safe in breast cancer patients receiving AC/EC: study
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Fosnetupitant (FosNTP) demonstrated favourable safety as Anti-emetic for breast cancer patients receiving chemotherapy, according to a recent study published in journal cancer.

A previous phase 2 study had shown a favourable safety profile and antiemetic activity of FosNTP in patients receiving cisplatin-based chemotherapy.

Breast cancer can occur in women and rarely in men. Symptoms of breast cancer include a lump in the breast, bloody discharge from the nipple and changes in the shape or texture of the nipple or breast. Its treatment depends on the stage of cancer. It may consist of chemotherapy, radiation, hormone therapy and surgery.

Advances in screening and treatment for breast cancer have improved survival rates dramatically. Overall, the rate of breast cancer declined by about 40%Trusted Source between 1989 and 2017. A 2019 study showed, however, that the rate in the United States may no longer be declining in women aged 20–39 years.

In the randomized, double-blind, multicenter, phase 3, CONSOLE-BC trial, 102 patients with breast cancer treated with AC/EC chemotherapy were randomly assigned to receive either FosNTP or fosaprepitant (FosAPR), both in combination with intravenous palonosetron and dexamethasone.

The primary outcome was the incidence of treatment-related adverse events (TRAEs). The funding was given by Taiho Pharmaceutical Co., Ltd.

Key results of the study:

TRAEs were seen in 21.2% (95% CI, 11.1%-34.7%) of patients in the FosNTP group vs 22.0% (95% CI, 11.5%-36.0%) in the FosAPR group.

The frequency of TRAEs relevant to injection site reactions was 5.8% in the FosNTP group vs 26.0% in the FosAPR group.

Grade 3 or higher TRAEs occurred in 9.6% of patients in the FosNTP group vs 0% in the FosAPR group, with none resulting in death or treatment discontinuation.

Thus, Anti-emetic Fosnetupitant (FosNTP) demonstrated favorable safety, with a low risk of injection-site reactions in patients with breast cancer receiving chemotherapy with doxorubicin-cyclophosphamide or epirubicin-cyclophosphamide (AC/EC).

Reference:

Antiemetic fosnetupitant safe in breast cancer patients receiving anthracycline-cyclophosphamide by Matsuura K & al published in the Medscape.

For further reference log on to:

https://doi.org/10.1002/cncr.34088


breast cancerAntiemeticfosnetupitantsafeanthracycline-cyclophosphamide
Source : Medscape
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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