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Early family history-based screening of colorectal cancer may lead to better detection

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2020-04-20T17:45:05+05:30  |  Updated On 20 April 2020 5:45 PM IST
Early family history-based screening of colorectal cancer may lead to better detection
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Current guidelines recommend that early screening for colorectal cancer among individuals with a family history of the disease to identify those at risk of colorectal cancer.

In an analysis that included information on adults diagnosed with colorectal cancer between 40 and 49 years of age, almost all patients could have been diagnosed earlier if they had been screened according to current family history-based screening guidelines. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS).

In many countries, colorectal cancer rates are rising in adults under 50 years of age. To identify those at risk, current guidelines recommend early screening for colorectal cancer among individuals with a family history of the disease. For example, for individuals with a first-degree relative with colorectal cancer, several medical societies recommend initiating screening at 40 years of age or 10 years prior to the age at diagnosis of the youngest relative diagnosed with colorectal cancer.

To estimate the potential impact of family history-based guidelines for screening, Samir Gupta, MD, of the VA San Diego Healthcare System and the University of California San Diego, and his colleagues examined information on individuals 40 to 49 years of age--2,473 with colorectal cancer and 772 without--in the Colon Cancer Family Registry from 1998 to 2007. (The Colon Cancer Family Registry contains information and specimens contributed by more than 15,000 families around the world and across the spectrum of risk for colorectal cancer).

The investigators found that 25 percent of individuals with colorectal cancer and 10 percent of those without cancer met the criteria for family history-based early screening. Almost all (98.4 percent) patients with colorectal cancer who met these criteria should have been screened at a younger age than when their cancer was diagnosed. Therefore, they could have had their cancer diagnosed earlier, or possibly even prevented, if earlier screening had been implemented based on family history-based guidelines.

"Our findings suggest that using family history-based criteria to identify individuals for earlier screening is justified and has promise for helping to identify individuals at risk for young-onset colorectal cancer," said Dr. Gupta. "We have an opportunity to improve early detection and prevention of colorectal cancer under age 50 if patients more consistently collect and share their family history of colorectal cancer, and healthcare providers more consistently elicit and act on family history."

For more details click on the link: http://dx.doi.org/10.1002/cncr.32851

screeningcolorectal canceramerican cancer society
Source : Cancer
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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