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  • New biosensor can...

New biosensor can detect breast cancer at early stage: Study

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-05-22T09:00:26+05:30  |  Updated On 22 May 2021 9:00 AM IST
New biosensor can detect breast cancer at early stage: Study
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Spain: A team of researchers from Spain has developed a prototype of a new biosensor, at the laboratory level, for the early detection of breast cancer, according to a recent study in the journal ACS Sensors.

Currently, mammography is the most widely used standard technique for breast cancer diagnosis, but it has some limitations, such as exposure to radiation, and lower sensitivity and specificity in young women with dense breast tissue. "Therefore, new diagnostic tools are needed to aid in the early detection of breast cancer. Our biosensor is along these lines," explains Ana Lluch, Biomedical Research Institute INCLIVA, Valencia, Spain.

The development of this biosensor falls within the field known as liquid biopsy, which helps detect the presence of cancer through a blood test. The mesoporous biosensor developed by the UPV-INCLIVA team is easy to use, low cost, and provides results in a very short time -between 30 and 60 minutes- from a sample of the patient's plasma.

The biosensor is composed of a nanomaterial -a nanoporous alumina- that facilitates the detection in plasma of miR-99a-5p microRNA, which is associated with breast cancer. Until now, this has been done by using complex and time-consuming techniques, which means that this system could not be used as a diagnostic tool in the clinical setting.

Martínez Máñez explains how their alternative diagnostic system works: the nanopores of the biosensor are loaded with a dye -rhodamine B- and sealed with an oligonucleotide. When interacting with the plasma sample, if the pore gates do not detect the presence of the microRNA, they remain closed; in contrast, in the presence of miR-99a-5p, the pore gates open and the dye is released. "The change in dye release can be correlated with either healthy or breast cancer patients," summarises Martínez Máñez.

Staff from the IIS La Fe Institute for Health Research, where the tests for the validation of the new biosensors have been carried out, and the Networking Biomedical Research Centre in Cancer (CIBERONC) have also participated in the development of this biosensor.

"The next step in our work will be validating our system in a larger group of patients," concludes Ramón Martínez Máñez.

Reference:

The study titled, "Nanoporous Anodic Alumina-Based Sensor for miR-99a-5p Detection as an Effective Early Breast Cancer Diagnostic Tool," is published in the journal ACS Sensors.

DOI: https://pubs.acs.org/doi/10.1021/acssensors.0c02222#

breast canceracs sensorsbiosensor
Source : ACS Sensors
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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