Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • MD Brand Connect
  • Vaccine Hub
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
  • Fact Check
  • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Fact Check
      • Bone Health Fact Check
      • Brain Health Fact Check
      • Cancer Related Fact Check
      • Child Care Fact Check
      • Dental and oral health fact check
      • Diabetes and metabolic health fact check
      • Diet and Nutrition Fact Check
      • Eye and ENT Care Fact Check
      • Fitness fact check
      • Gut health fact check
      • Heart health fact check
      • Kidney health fact check
      • Medical education fact check
      • Men's health fact check
      • Respiratory fact check
      • Skin and hair care fact check
      • Vaccine and Immunization fact check
      • Women's health fact check
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Abroad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
      • Medical Dialogues Show
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Fact Check
    • Bone Health Fact Check
    • Brain Health Fact Check
    • Cancer Related Fact Check
    • Child Care Fact Check
    • Dental and oral health fact check
    • Diabetes and metabolic health fact check
    • Diet and Nutrition Fact Check
    • Eye and ENT Care Fact Check
    • Fitness fact check
    • Gut health fact check
    • Heart health fact check
    • Kidney health fact check
    • Medical education fact check
    • Men's health fact check
    • Respiratory fact check
    • Skin and hair care fact check
    • Vaccine and Immunization fact check
    • Women's health fact check
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Abroad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Urology
  • Urology News
  • PARPi olaparib...

PARPi olaparib increases survival rate of metastatic prostate cancer, finds study

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2020-09-25T17:15:00+05:30  |  Updated On 26 Sept 2020 3:40 PM IST
PARPi olaparib increases survival rate of metastatic prostate cancer, finds study
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • Email

Results from the PROfound phase III study, open up a much-needed new treatment avenue for the more precise and effective treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) whose disease has progressed with hormonal therapy.

The PROfound trial investigators show significantly longer overall survival of mCRPC patients with at least one alteration in BRCA1, BRCA2, or ATM genes, who received treatment with PARP inhibitor olaparib versus enzalutamide or abiraterone plus prednisone.

Ringing in a new era of precision medicine to more effectively combat this lethal disease, it is the first time that a PARPi has shown an increased survival rate in a prospective clinical trial. PROfound also demonstrates the importance of incorporating genomic sequencing for the optimal stratification of mCRPC patients.

Barcelona, 20 September 2020- In the quest to establish more potent treatment strategies that target vulnerabilities in BRCA1/2-associated cancers+, PARP inhibitor (PARPi) olaparib continues to drive more precise and personalized therapeutic approaches. By extending survival and reducing risk of disease progression, this anti-cancer therapy has been approved for the treatment of both BRCA1/2 mutated advanced breast and ovarian cancers, and is also licensed as maintenance therapy after response to platinum-based chemotherapy for the latter.

Revealed today during the second Presidential Session of the European Society for Medical Oncology's (ESMO) Virtual Congress 2020 (19-21 September), findings from the PROfound open-label, randomised phase III study evidence the efficacy of olaparib for the targeted treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) with at least one alteration in BRCA1, BRCA2, or ATM genes. Presented by second author Joaquin Mateo, Principal Investigator of the Vall d'Hebron Institute of Oncology's (VHIO) Prostate Cancer Translational Research Group, this practice-changing data has published simultaneously as an Original Article in the New England Journal of Medicine.

Building on previous findings first-authored by Joaquin Mateo*, showing that olaparib leads to tumor responses in mCRPC patients with DNA-damage repair (DDR) alterations who had previously received chemotherapy and were no longer responding to standard treatments, the PROfound investigators now show significantly longer overall survival in this patient population who were treated with olaparib versus standard therapy with enzlutamide or abiraterone plus prednisone.

This present research, spearhead by Maha Hussain, the Robert H. Lurie Comprehensive Cancer Center (Chicago, USA), and Johann de Bono, the Institute of Cancer Research and Royal Marsden (London, UK), has led to the approval of olapirib by the U.S. Food and Drug Administration (FDA) for the treatment of this disease. In addition, clinical guidelines have been elaborated by ESMO, the National Comprehensive Cancer Network (NCCN), and American Urological Association (AUA), among others, that now recommend genomic sequencing of patients with advanced prostate cancer to identify which patients would most likely benefit from this novel and personalized treatment approach.

Commenting for VHIO's Global Communications second author of the study, Joaquin Mateo, who is also a Medical Oncologist at the Vall d'Hebron University Hospital (Vall d'Hebron Barcelona Hospital Campus) said, "The relevance of our results is reflected by the fact that the FDA has already authorized olaparib for the treatment of metastatic castration-resistant prostate cancer. Based on these data, this week the European Medicines Agency recommended the approval of olaparib for prostate cancer patients with BRCA1 or BRCA2 mutations, irrespective of somatic or germline. We expect to have the treatment available for patients in the clinic soon."

The PROfound Trial consisted of two cohorts: A included 245 patients with at least one alteration in BRCA1, BRCA2 or ATM, the most common and well-known mutations in this subtype of prostate tumors, and B with 142 patients who had a least one alteration in any of the other 12 prespecified genes. Alterations in these genes, whose function is related to BRCA1 or BRCA2, are found in between 10-15% of these cancers. "Cohort B was more exploratory given that there is little data on these genes individually. We sought to establish whether any of the twelve might be as relevant as those in cohort A in identifying patients who may benefit from olaparib. More information on these less frequent subgroups is required because some may well be important," noted Joaquin.

The ratio of patients treated with olaparib to patients treated with standard drugs was 2 to 1, with 256 patients treated with olaparib and 131 with hormonal therapy (enzalutamide or abiraterone plus prednisone). All patients had previously received hormonal therapy.

The results showed that the median survival increased, particularly in cohort A, in which the survival rate increased from 14.7 months with standard treatment to 19.1 months in the olaparib arm of the study, which indicates a reduced risk of death of 31%. In cohort B, the survival rate increased from 11.5 months to 14.1 months.

"While our results show that olaparib is effective in patients with DNA repair gene mutations, even within this group we identified differences depending on the specific gene of each patient. Mutations in BRCA1 and BRCA2 are those clearly associated with the greatest benefit. For genes whose mutations are not very prevalent, more studies are warranted," added Joaquin.

By showing that certain genomic profiles benefit from treatment with olaparib, this study represents a paradigm shift in the treatment of this subpopulation of patients. Specifically, it supports the implementation of genomic stratification of patients with mCRPC, who do not respond to treatment with hormonal therapy in clinical practice based on tumor sequencing.

He concluded, "This gene-targeted approach could help more precisely guide treatment decisions as well as match more effective therapies to the molecular make up of individual patients' tumors. The challenge that lies ahead will be implementing genomic testing in clinical practice, especially because, unlike breast or ovarian cancer, these BRCA1 or BRCA2 mutations are not necessarily hereditary. It is therefore imperative to sequence tumor biopsies, beyond just normal tissues or blood from patients."

https://www.nejm.org/doi/10.1056/NEJMoa2022485

hormonal therapymetastatic prostate cancerdementiaabiraterone plus prednisoneparp inhibitor olaparibnew england journal of medicine
Source : New England Journal of Medicine
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

    Show Full Article
    Next Story

    Editorial

    Dapagliflozin Shines in Post-TAVI Patients:DAPA-TAVI Trial Findings

    Dapagliflozin Shines in Post-TAVI Patients:DAPA-TAVI Trial Findings

    Identifying Candidates for Aspirin in Primary Prevention: Men Aged 40-50 with Hypertension, Dyslipidemia, and Familial ASCVD Risk

    Identifying Candidates for Aspirin in Primary Prevention: Men Aged 40-50 with Hypertension,...

    Featured image representing thinking

    Is Pharma Marketing Going Through "Thinking Recession"?

    Beyond BMI: Why Pioglitazone Deserves a Place in Managing Thin-Fat Type 2 Diabetes in India

    Beyond BMI: Why Pioglitazone Deserves a Place in Managing 'Thin-Fat' Type 2 Diabetes in India

    How to Improve Adherence in Hypertensive Patients? Bridging the Gap with CONNECT Tool

    How to Improve Adherence in Hypertensive Patients? Bridging the Gap with CONNECT Tool

    View All

    Journal Club Today

    Exfoliation Explained by Dermatologist Dr. Tanvi Vaidya

    Exfoliation Explained by Dermatologist Dr. Tanvi Vaidya

    View All

    Health News Today

    Health Bulletin 2/July/ 2025

    Health Bulletin 2/July/ 2025

    View All
    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    X
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok