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Positive oral CT contrast improves detection of malignant deposits in intraabdominal nonsolid organs
Leesburg: According to ARRS' American Journal of Roentgenology (AJR), the selection of oral contrast agent and optimization of bowel preparation for oncologic CT could help avoid potentially severe clinical consequences of missed malignant deposits.
"CT has suboptimal NPV for malignant deposits in intraabdominal nonsolid organs," wrote corresponding author Benjamin M. Yeh of the University of California, San Francisco. "Compared to neutral material, positive oral contrast material improves detection, particularly with adequate bowel filling."
Yeh and team's retrospective study included 265 patients (133 men, 132 women; median age, 61 years) who underwent an abdominopelvic CT examination where the report did not suggest presence of malignant deposits and subsequent CT examination within 6 months where the report indicated at least one unequivocal malignant deposit. Examinations used positive (iohexol; n=100) or neutral (water; n=165) oral agents. While reviewing images to assess visibility of deposits, a board-certified abdominal radiologist also assessed adequacy of bowel filling with oral contrast material.
NPV of CT for detection of malignant deposits in intraabdominal nonsolid organs was 65.8% for examinations using positive oral contrast material with adequate bowel filling, 45.2% for positive oral contrast material with inadequate bowel filling (p=.07), and 35.2% for neutral oral contrast material regardless of adequacy of bowel filling (p=.002).
"Results may differ when studying other types of contrast material regimens," the authors of this AJR article noted, including barium-based, hyperosmolar iodine, sugar-alcohol neutral, or experimental dark oral agents.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751