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  • Research alert: High...

Research alert: High cannabis use linked to increased mortality in colon cancer patients

Dr. Kamal Kant KohliWritten by Dr. Kamal Kant Kohli Published On 2025-05-04T20:30:32+05:30  |  Updated On 4 May 2025 8:30 PM IST
Research alert: High cannabis use linked to increased mortality in colon cancer patients
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Researchers at the University of California San Diego School of Medicine have found that individuals with colon cancer and a documented history of high cannabis use were more than 20 times more likely to die within five years of diagnosis compared to those without such a history.

“This study adds to a growing body of evidence suggesting that heavy cannabis use may have underrecognized impacts on the immune system, mental health and treatment behaviors-all of which could influence cancer outcomes,” said lead author Raphael Cuomo, Ph.D., associate professor in the Department of Anesthesiology at UC San Diego School of Medicine.

The research team drew on electronic health records from more than 1,000 colon cancer patients treated across the University of California Health system between 2012 and 2024. They evaluated how cancer outcomes differed based on patients’ documented cannabis use before diagnosis, controlling for age, sex and indicators of disease severity such as tumor staging and cancer biomarkers.

The analysis found:

• Patients with a history of cannabis use disorder (CUD) had a substantially higher five-year mortality rate (55.88 %) compared to patients without CUD (5.05 %).

• Patients diagnosed with CUD prior to cancer diagnosis were 24.4 times more likely to die within five years of diagnosis compared to those without CUD.

While some laboratory studies have shown anti-tumor effects from certain cannabis compounds, the authors note that real-world use is more complex. Given the increasing prevalence and social acceptance of cannabis use, they also emphasize the need to further investigate its long-term effects in medically vulnerable populations.

“High cannabis use is often associated with depression, anxiety and other challenges that may compromise a patient’s ability to engage fully with cancer treatment,” said Cuomo, who is also a member of UC San Diego Moore’s Cancer Center. “However, this isn’t about vilifying cannabis. It’s about understanding the full range of its impacts, especially for people facing serious illnesses. We hope these findings encourage more research-and more nuanced conversations-about how cannabis interacts with cancer biology and care.”

Reference:

Raphael E. Cuomo, Cannabis use disorder and mortality among patients with colon cancer, Annals of Epidemiology, https://doi.org/10.1016/j.annepidem.2025.04.012.

Annals of Epidemiologycannabiscolon cancercancer
Source : Annals of Epidemiology
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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