Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • Medical Jobs
  • Medical Matrimony
  • MD Brand Connect
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • MCI News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Aborad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • MCI News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Oncology
  • Oncology News
  • Researchers report...

Researchers report novel findings for breast cancer patients with obesity, diabetes

Hina ZahidWritten by Hina Zahid Published On 2021-12-11T09:00:18+05:30  |  Updated On 11 Dec 2021 3:30 AM GMT
Researchers report novel findings for breast cancer patients with obesity, diabetes
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • koo
  • Email

Boston -Obesity, insulin resistance and Type 2 diabetes are risk factors for breast cancer in post-menopausal women. The metabolic and inflammatory complications of obesity have a role in the formation of cancer. However, the cellular and molecular pathways that mediate breast cancer incidence, progression and metastasis in patients who also have metabolic complications are still not...

Boston -Obesity, insulin resistance and Type 2 diabetes are risk factors for breast cancer in post-menopausal women. The metabolic and inflammatory complications of obesity have a role in the formation of cancer. However, the cellular and molecular pathways that mediate breast cancer incidence, progression and metastasis in patients who also have metabolic complications are still not fully understood.

For the first time, researchers have found that exosomes (small vesicles secreted by many cell types and released into blood or nearby tissues and fluids), are involved in breast cancer progression and treatment resistance.

"We have identified a potential biological difference that might explain this higher risk and inform clinical decision making. This novel biology may also suggest new drugs or treatments to reduce risk for metastasis in cancer patients who are also obese and diabetic," explained corresponding author Gerald V. Denis, PhD, professor of medicine and pharmacology, and Shipley Professor, at Boston University School of Medicine.

Currently, more than 100 million Americans are currently diabetic or pre-diabetic with 90 percent of these cases due to obesity. If these adults develop an obesity-driven cancer, there is higher likelihood that the cancer will metastasize or become resistant to targeted treatments or hormone therapies.

The researchers isolated and characterized exosomes to identify factors that promote breast cancer progression and metastasis. They found that exosomes from insulin resistant adipocytes (fat cells), or from adipose tissue of adults with Type 2 diabetes, provoked much more dangerous changes in human breast cancer cells than exosomes from insulin sensitive or non-diabetic adipocytes.

According to Denis, metabolic diagnoses (blood glucose, A1c levels, lipid profiles, elevated insulin, cardiovascular risk markers like elevated CRP) are not normally considered by oncologists who are evaluating the risk of breast cancer progression, treatment resistance or recurrence. "It has also been difficult to identify blood tests that would assist clinicians to plan treatment or change treatment plans, because clinical trials have not yet been conducted to define the most important biomarkers. Inexpensive diagnostic and prognostic tests that are covered by insurance and that require only a small amount of blood would help oncologists improve treatment for these patients," he said.

Denis believes this discovery has implications for any obesity-related cancer (breast cancer in post-menopausal women, ovarian, uterine/endometrial, and (in men) prostate cancer, and (in both men and women) colorectal, gallbladder, renal, pancreatic, hepatic, thyroid, esophageal adenocarcinoma, and multiple myeloma) where nearby fat deposits may be metabolically abnormal and inflamed.

https://www.science.org/doi/10.1126/scisignal.abj2807

breast cancerobesitydiabetesscience signaling
Source : Science Signaling
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Show Full Article
    Next Story
    Similar Posts
    NO DATA FOUND

    Editorial

    Journal Club Today

    Health News Today

    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    X
    X