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  • Brepocitinib...

Brepocitinib Demonstrates Promising Phase 2 Results in Uveitis Treatment

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-04-12T04:15:43+05:30  |  Updated On 12 April 2024 4:15 AM IST
Brepocitinib Demonstrates Promising Phase 2 Results in Uveitis Treatment
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Priovant Therapeutics recently unveiled promising results from the NEPTUNE Phase 2 study by testing the efficacy of brepocitinib in patients with non-anterior non-infectious uveitis (NIU) which can lead to severe visual impairment. This study highlights the potential of brepocitinib to revolutionize treatment paradigms in autoimmunity by specifically targeting a condition with few effective treatments currently available.

The study evaluated a total of 26 subjects with active NIU and they were randomized to receive either 45 mg or 15 mg doses of brepocitinib. Remarkably, at week 24, the treatment failure rate was significantly lower in the 45 mg group (29%) when compared to the 15 mg group (44%) that indicates a substantial improvement in the disease management. Furthermore, the rate of treatment failure due to disease activity was reduced to 18% in the higher dose group which highlights the effectiveness of brepocitinib.

The NEPTUNE study marked brepocitinib 45 mg to have the most favorable treatment failure rates among active NIU studies and additionally highlights its positive impact across all secondary efficacy endpoints. Also, the patients experienced significant improvements in the prevention and treatment of uveitic macular edema that can lead to vision loss.

With over 1,400 subjects treated in clinical trials, brepocitinib demonstrated a consistent safety profile similar to the approved JAK inhibitors without the identification of new safety concerns. This positions brepocitinib as a potential therapy for the autoimmunity, specially with ongoing studies in dermatomyositis and the anticipated initiation of a pivotal NIU program.

A NEPTUNE investigator emphasized the urgent need for more effective treatments for non-infectious uveitis that remained as a significant cause of blindness in the U.S. The results on brepocitinib points to its potential as a transformative oral therapy for this debilitating disease. The dual inhibition mechanism of the drug offers a targeted approach to suppressing key cytokines involved in the autoimmunity.

The CEO of Priovant expressed excitement over the outcomes of the study and the dose-dependent benefits observed across various measures of disease activity. He highlighted the rigor of the NEPTUNE study design to minimize false positives by strengthening the confidence in moving forward to Phase 3. The pipeline of Priovant Therapeutics is to launch a Phase 3 program in NIU in late 2024, with the ongoing efforts in dermatomyositis that is expected to yield results by 2025.

Source:

Therapeutics, P. (2024, April 2). Priovant therapeutics announces positive phase 2 NEPTUNE study results for brepocitinib in non-infectious uveitis (NIU), showing strongest efficacy data in NIU observed to date. PR Newswire. https://www.prnewswire.com/news-releases/priovant-therapeutics-announces-positive-phase-2-neptune-study-results-for-brepocitinib-in-non-infectious-uveitis-niu-showing-strongest-efficacy-data-in-niu-observed-to-date-302105011.html

Priovant TherapeuticsNon-infectious uveitisbrepocitinib
Source : Priovant Therapeutics
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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