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  • Oral intake of 7-MX...

Oral intake of 7-MX promising for arresting myopia progression in children

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-04-07T09:45:41+05:30  |  Updated On 7 April 2023 4:12 PM IST
Oral intake of 7-MX promising for arresting myopia progression in children
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Researchers have found in a new study that Oral intake of 7-methylxanthine (7-MX) is associated with reduced myopia progression and axial elongation in children.

The study has been published in the British Journal of Ophthalmology.

Myopia is associated with an increased risk of permanent vision loss. The caffeine metabolite 7-methylxanthine (7-MX), licensed in Denmark since 2009 as a treatment to reduce the rate of childhood myopia progression, is the only orally administered therapy available. The purpose of the current study was to assess the rate of myopia progression in children taking 7-MX.

Longitudinal cycloplegic refraction and axial length data for 711 myopic children from Denmark treated with varying doses of oral 7-MX (0–1200 mg per day) were analysed using linear mixed models.

The Results of the study are:

  • The median age at baseline was 11.1 years
  • Children were followed for an average of 3.6 years and the average myopia progression was 1.34 dioptres (D)
  • Treatment with 7-MX was associated with a reduced rate of myopia progression and axial elongation
  • Modelling suggested that, on average, an 11-year-old child taking 1000 mg 7-MX daily would develop −1.43 D of myopia over the next 6 years, compared with −2.27 D if untreated.
  • Axial length in this child would increase by 0.84 mm over 6 years when taking a daily dose of 1000 mg of 7-MX, compared with 1.01 mm if untreated.
  • No adverse effects of 7-MX therapy were reported.

The researchers have concluded that oral intake of 7-MX was associated with reduced myopia progression and reduced axial elongation in this sample of myopic children from Denmark. Randomised controlled trials are needed to determine whether the association is causal.

Reference:

Trier K, et al "Oral administration of caffeine metabolite 7-methylxanthine is associated with slowed myopia progression in Danish children" Br J Ophthalmol 2022; DOI: 10.1136/bjo-2021- 320920

OralSupplementChildhood MyopiaBritish Journal of Ophthalmology
Source : British Journal of Ophthalmology
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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