- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Two regimens of intravitreal Conbercept improve outcomes in polypoidal choroidal vasculopathy: STAR study.
A new study found that both the fixed dosing regimen and the treat-and-extend regimen of intravitreal conbercept (IVC) resulted in improvement in visual and anatomical outcomes in polypoidal choroidal vasculopathy (PCV) patients. The study results were published in the journal Acta Ophthalmologica.
Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration (nAMD). Out of the multiple therapeutic options, available Conbercept is a novel fusion protein used for the management of nAMD. Previous literature has shown the efficacy of conbercept in nAMD but there is meager information on the optimal treatment strategy for use in clinical practice. Hence researchers conducted a multicenter, parallel, open-label, randomized clinical trial in 32 eye centers in China to compare the efficacy and safety of two different treatment regimens of IVC for PCV.
249 patients who are treatment naïve with PCV were randomized 1:1 to two groups. They are the fixed dosing regimen group with injections given every 12 weeks (3 + Q12W) and the treat-and-extend regimen (3 + TAE) group. A loading dose of 3 monthly 0.5 mg intravitreal injections of conbercept was given to patients as a loading dose in both groups. The 3 + Q12W patients were monitored monthly and received mandated injections every 12 weeks; the 3 + TAE patients were monitored and treated monthly until the resolution of exudative disease activity. The interval between visits was then individualized according to the study protocol. Visual and anatomical outcomes were compared between the two groups.
Results:
- At 48 weeks, there was no significant difference between the 3 + Q12W group and 3 + TAE group in the following
mean BCVA improvement | (p = 0.421) |
mean changes in central retinal thickness (CRT) | (p = 0.818) |
maximum retinal thickness (MRT) | (p = 0.448) |
pigment epithelial detachment (PED) height | (p = 0.221) |
PED volume | (p = 0.076) |
branching vascular network (BVN) area | (p = 0.615) |
polypoidal lesion number | (p = 0.701) |
polypoidal lesion area | (p = 0.424) |
rates of patients who avoided vision loss of ≥15 ETDRS letters | (p = 0.397) |
complete polypoidal lesion regression rate | (p = 0.814) |
- The 3 + Q12W group had more decreased retinal hemorrhage area (p = 0.014) and fewer mean numbers of injections compared with the 3 + TAE group (6.6 vs. 9.4, p < 0.001).
- The mean maximum extension interval between injections after loading injections was 9.6 ± 2.0 weeks for the 3 + TAE group. An extension interval of 12 weeks was achieved by 27.8% of patients and 61.1% of patients achieved 8 weeks or more.
Thus, in PCV patients both the fixed dosing regimen and treat-and-extend regimens of IVC resulted in improvements in visual and anatomical outcomes.
Further reading: Li X, Qu J, Su G, et al. The comparison of two different strategies of intravitreal conbercept for polypoidal choroidal vasculopathy in Chinese patients results from a 48-week randomized phase 4 study: STAR study [published online ahead of print, 2022 Oct 18]. Acta Ophthalmol. 2022;10.1111/aos.15272. doi:10.1111/aos.15272
BDS, MDS
Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751